Breast cancer stem-like cells are inhibited by diosgenin, a steroidal saponin, by the attenuation of the Wnt β-catenin signaling via the Wnt antagonist secreted frizzled related protein-4

• Main Authors: Bhuvanalakshmi, G, Basappa, Laboratory of Chemical Biology, Department of Chemistry, Bangalore University, Bangalore, India, Rangappa, K.S, Dharmarajan, A, Sethi, G, Kumar, A.P, Warrier, S
• Other Authors: DEPT OF PHARMACOLOGY
• Format: Article
• Published: 2020
• Subjects: aldehyde dehydrogenase; beta catenin; caspase 3; caspase 7; diosgenin; glycogen synthase kinase 3beta; Hermes antigen; reactive oxygen metabolite; secreted frizzled related protein 4; Wnt protein; antiangiogenic activity; antineoplastic activity; antiproliferative activity; apoptosis; Article; breast cancer cell line; cancer inhibition; cancer stem cell; cell cycle checkpoint; cell self-renewal; chick; controlled study; drug efficacy; embryo; epithelial mesenchymal transition; G0 phase cell cycle checkpoint; gene expression; loss of function mutation; migration inhibition; nonhuman; protein expression; Wnt signaling pathway
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181291
• Institution: National University of Singapore

10.3389/fphar.2017.00124