Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1

10.1186/s12943-016-0550-2

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Bibliographic Details
Main Authors:	Arora, R, Sawney, S, Saini, V, Steffi, C, Tiwari, M, Saluja, D
Other Authors:	ORTHOPAEDIC SURGERY
Format:	Article
Published:	2020
Subjects:	caspase 3 caspase 8 caspase 9 esculetin immunoglobulin enhancer binding protein kelch like ECH associated protein 1 reactive oxygen metabolite transcription factor Nrf2 transcription factor RelA antineoplastic agent antioxidant caspase protein binding umbelliferone derivative antiproliferative activity apoptosis Article cancer inhibition controlled study drug cytotoxicity drug protein binding G1 phase cell cycle checkpoint gene expression human human cell mitochondrion molecular docking pancreas cancer pancreatic cancer cell line protein protein interaction upregulation cell cycle cell proliferation cell survival chemistry conformation drug effects metabolism mitochondrial membrane potential molecular model pancreas tumor tumor cell line Antineoplastic Agents Antioxidants Apoptosis Caspases Cell Cycle Cell Line, Tumor Cell Proliferation Cell Survival Humans Kelch-Like ECH-Associated Protein 1 Membrane Potential, Mitochondrial Models, Molecular Molecular Conformation NF-kappa B Pancreatic Neoplasms Protein Binding Reactive Oxygen Species Umbelliferones
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/181336
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Institution:	National University of Singapore

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