Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1

10.1186/s12943-016-0550-2

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Main Authors:	Arora, R, Sawney, S, Saini, V, Steffi, C, Tiwari, M, Saluja, D
Other Authors:	ORTHOPAEDIC SURGERY
Format:	Article
Published:	2020
Subjects:	caspase 3 caspase 8 caspase 9 esculetin immunoglobulin enhancer binding protein kelch like ECH associated protein 1 reactive oxygen metabolite transcription factor Nrf2 transcription factor RelA antineoplastic agent antioxidant caspase protein binding umbelliferone derivative antiproliferative activity apoptosis Article cancer inhibition controlled study drug cytotoxicity drug protein binding G1 phase cell cycle checkpoint gene expression human human cell mitochondrion molecular docking pancreas cancer pancreatic cancer cell line protein protein interaction upregulation cell cycle cell proliferation cell survival chemistry conformation drug effects metabolism mitochondrial membrane potential molecular model pancreas tumor tumor cell line Antineoplastic Agents Antioxidants Apoptosis Caspases Cell Cycle Cell Line, Tumor Cell Proliferation Cell Survival Humans Kelch-Like ECH-Associated Protein 1 Membrane Potential, Mitochondrial Models, Molecular Molecular Conformation NF-kappa B Pancreatic Neoplasms Protein Binding Reactive Oxygen Species Umbelliferones
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/181336
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Institution:	National University of Singapore

id	sg-nus-scholar.10635-181336
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spelling	sg-nus-scholar.10635-1813362024-04-18T06:55:43Z Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1 Arora, R Sawney, S Saini, V Steffi, C Tiwari, M Saluja, D ORTHOPAEDIC SURGERY caspase 3 caspase 8 caspase 9 esculetin immunoglobulin enhancer binding protein kelch like ECH associated protein 1 reactive oxygen metabolite transcription factor Nrf2 transcription factor RelA antineoplastic agent antioxidant caspase esculetin immunoglobulin enhancer binding protein kelch like ECH associated protein 1 protein binding reactive oxygen metabolite umbelliferone derivative antiproliferative activity apoptosis Article cancer inhibition controlled study drug cytotoxicity drug protein binding G1 phase cell cycle checkpoint gene expression human human cell mitochondrion molecular docking pancreas cancer pancreatic cancer cell line protein protein interaction upregulation apoptosis cell cycle cell proliferation cell survival chemistry conformation drug effects metabolism mitochondrial membrane potential molecular model pancreas tumor tumor cell line Antineoplastic Agents Antioxidants Apoptosis Caspases Cell Cycle Cell Line, Tumor Cell Proliferation Cell Survival Humans Kelch-Like ECH-Associated Protein 1 Membrane Potential, Mitochondrial Models, Molecular Molecular Conformation NF-kappa B Pancreatic Neoplasms Protein Binding Reactive Oxygen Species Umbelliferones 10.1186/s12943-016-0550-2 Molecular Cancer 15 1 64 2020-10-27T10:36:51Z 2020-10-27T10:36:51Z 2016 Article Arora, R, Sawney, S, Saini, V, Steffi, C, Tiwari, M, Saluja, D (2016). Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1. Molecular Cancer 15 (1) : 64. ScholarBank@NUS Repository. https://doi.org/10.1186/s12943-016-0550-2 14764598 https://scholarbank.nus.edu.sg/handle/10635/181336 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	caspase 3 caspase 8 caspase 9 esculetin immunoglobulin enhancer binding protein kelch like ECH associated protein 1 reactive oxygen metabolite transcription factor Nrf2 transcription factor RelA antineoplastic agent antioxidant caspase esculetin immunoglobulin enhancer binding protein kelch like ECH associated protein 1 protein binding reactive oxygen metabolite umbelliferone derivative antiproliferative activity apoptosis Article cancer inhibition controlled study drug cytotoxicity drug protein binding G1 phase cell cycle checkpoint gene expression human human cell mitochondrion molecular docking pancreas cancer pancreatic cancer cell line protein protein interaction upregulation apoptosis cell cycle cell proliferation cell survival chemistry conformation drug effects metabolism mitochondrial membrane potential molecular model pancreas tumor tumor cell line Antineoplastic Agents Antioxidants Apoptosis Caspases Cell Cycle Cell Line, Tumor Cell Proliferation Cell Survival Humans Kelch-Like ECH-Associated Protein 1 Membrane Potential, Mitochondrial Models, Molecular Molecular Conformation NF-kappa B Pancreatic Neoplasms Protein Binding Reactive Oxygen Species Umbelliferones
spellingShingle	caspase 3 caspase 8 caspase 9 esculetin immunoglobulin enhancer binding protein kelch like ECH associated protein 1 reactive oxygen metabolite transcription factor Nrf2 transcription factor RelA antineoplastic agent antioxidant caspase esculetin immunoglobulin enhancer binding protein kelch like ECH associated protein 1 protein binding reactive oxygen metabolite umbelliferone derivative antiproliferative activity apoptosis Article cancer inhibition controlled study drug cytotoxicity drug protein binding G1 phase cell cycle checkpoint gene expression human human cell mitochondrion molecular docking pancreas cancer pancreatic cancer cell line protein protein interaction upregulation apoptosis cell cycle cell proliferation cell survival chemistry conformation drug effects metabolism mitochondrial membrane potential molecular model pancreas tumor tumor cell line Antineoplastic Agents Antioxidants Apoptosis Caspases Cell Cycle Cell Line, Tumor Cell Proliferation Cell Survival Humans Kelch-Like ECH-Associated Protein 1 Membrane Potential, Mitochondrial Models, Molecular Molecular Conformation NF-kappa B Pancreatic Neoplasms Protein Binding Reactive Oxygen Species Umbelliferones Arora, R Sawney, S Saini, V Steffi, C Tiwari, M Saluja, D Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1
description	10.1186/s12943-016-0550-2
author2	ORTHOPAEDIC SURGERY
author_facet	ORTHOPAEDIC SURGERY Arora, R Sawney, S Saini, V Steffi, C Tiwari, M Saluja, D
format	Article
author	Arora, R Sawney, S Saini, V Steffi, C Tiwari, M Saluja, D
author_sort	Arora, R
title	Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1
title_short	Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1
title_full	Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1
title_fullStr	Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1
title_full_unstemmed	Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1
title_sort	esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to keap1
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/181336
_version_	1800914632520499200

Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1

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