Bevacizumab and Combination Chemotherapy in rectal cancer Until Surgery (BACCHUS): A phase II, multicentre, open-label, randomised study of neoadjuvant chemotherapy alone in patients with high-risk cancer of the rectum

• Main Authors: Glynne-Jones, R, Hava, N, Goh, V, Bosompem, S, Bridgewater, J, Chau, I, Gaya, A, Wasan, H, Moran, B, Melcher, L, MacDonald, A, Osborne, M, Beare, S, Jitlal, M, Lopes, A, Hall, M, West, N, Quirke, P, Wong, W.-L, Harrison, M, and for the Bacchus investigato
• Other Authors: SURGERY
• Format: Article
• Published: 2020
• Subjects: bevacizumab; fluorouracil; folinic acid; irinotecan; oxaliplatin; angiogenesis inhibitor; antineoplastic agent; advanced cancer; Article; cancer adjuvant therapy; cancer combination chemotherapy; cancer control; cancer grading; cancer prognosis; cancer regression; cancer size; cancer staging; colostomy; computer assisted emission tomography; continuous infusion; controlled study; disease free survival; drug efficacy; drug monitoring; drug safety; drug tolerability; feasibility study; follow up; high risk patient; histopathology; human; human tissue; multicenter study; multiple cycle treatment; nuclear magnetic resonance imaging; open study; outcome assessment; overall survival; patient compliance; phase 2 clinical trial; preoperative treatment; progression free survival; prospective study; randomized controlled trial; rectum cancer; rectum surgery; total mesorectal excision; treatment response; abdominal surgery; adjuvant chemotherapy; aged; clinical trial; combination drug therapy; female; male; neoadjuvant therapy; prognosis; Rectal Neoplasms; treatment outcome; Aged; Angiogenesis Inhibitors; Antineoplastic Agents; Bevacizumab; Chemotherapy, Adjuvant; Digestive System Surgical Procedures; Drug Therapy, Combination; Female; Humans; Male; Neoadjuvant Therapy; Prognosis; Prospective Studies; Treatment Outcome
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181427
• Institution: National University of Singapore

10.1186/s12885-015-1764-1