Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis

• Main Authors: Mencarelli, A, D'Amore, C, Renga, B, Cipriani, S, Carino, A, Sepe, V, Perissutti, E, D'Auria, M.V, Zampella, A, Distrutti, E, Fiorucci, S
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2020
• Subjects: C reactive protein; cell nucleus receptor; chemokine; collagen antibody; cytokine; gamma interferon; interleukin 10; interleukin 17; macrophage inflammatory protein 1alpha; pregnane derivative; pregnane X receptor; RANTES; solomonsterol A; tumor necrosis factor alpha; unclassified drug; adaptive immunity; animal experiment; animal model; antiinflammatory activity; article; controlled study; histopathology; immunopathology; inflammation; innate immunity; lymph node; male; mouse; nonhuman; rheumatoid arthritis; scoring system; sponge (Porifera); Theonella swinhoei; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; C-Reactive Protein; Cartilage; Chemokine CCL3; Chemokine CCL5; Cholanes; Collagen Type II; Cytokines; Hepatocytes; Humans; Immunologic Deficiency Syndromes; Interferon-gamma; Interleukin-17; Liver; Lymph Nodes; Mice, Inbred C57BL; Mice, Transgenic; Models, Molecular; Molecular Conformation; Porifera; Receptors, Steroid; Sulfuric Acid Esters; Transcriptional Activation; Tumor Necrosis Factor-alpha
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181535
• Institution: National University of Singapore

10.3390/md12010036