Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis

Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis

10.1186/ar3424

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Bibliographic Details
Main Authors:	Biniecka, M, Kennedy, A, Ng, C.T, Chang, T.C, Balogh, E, Fox, E, Veale, D.J, Fearon, U, O'Sullivan, J.N
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2020
Subjects:	mitochondrial DNA oxygen tumor necrosis factor inhibitor vasculotropin biological product tumor necrosis factor alpha arthritis article clinical article clinical assessment controlled study human immunohistochemistry inflammation lipid peroxidation mitochondrial genome mutagenesis nucleotide sequence oxidative stress oxygen tension synovitis synovium tissue oxygenation visual analog scale cell hypoxia drug antagonism drug effect genetics mitochondrion mutation reverse transcription polymerase chain reaction rheumatoid arthritis Arthritis, Rheumatoid Biological Agents Cell Hypoxia DNA, Mitochondrial Humans Immunohistochemistry Mitochondria Mutagenesis Mutation Oxidative Stress Oxygen Reverse Transcriptase Polymerase Chain Reaction Synovial Membrane Tumor Necrosis Factor-alpha
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/181630
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Institution:	National University of Singapore

Description
Summary:	10.1186/ar3424