Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis

10.1186/ar3424

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Main Authors:	Biniecka, M, Kennedy, A, Ng, C.T, Chang, T.C, Balogh, E, Fox, E, Veale, D.J, Fearon, U, O'Sullivan, J.N
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2020
Subjects:	mitochondrial DNA oxygen tumor necrosis factor inhibitor vasculotropin biological product tumor necrosis factor alpha arthritis article clinical article clinical assessment controlled study human immunohistochemistry inflammation lipid peroxidation mitochondrial genome mutagenesis nucleotide sequence oxidative stress oxygen tension synovitis synovium tissue oxygenation visual analog scale cell hypoxia drug antagonism drug effect genetics mitochondrion mutation reverse transcription polymerase chain reaction rheumatoid arthritis Arthritis, Rheumatoid Biological Agents Cell Hypoxia DNA, Mitochondrial Humans Immunohistochemistry Mitochondria Mutagenesis Mutation Oxidative Stress Oxygen Reverse Transcriptase Polymerase Chain Reaction Synovial Membrane Tumor Necrosis Factor-alpha
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/181630
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Institution:	National University of Singapore

id	sg-nus-scholar.10635-181630
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spelling	sg-nus-scholar.10635-1816302023-11-01T07:41:56Z Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis Biniecka, M Kennedy, A Ng, C.T Chang, T.C Balogh, E Fox, E Veale, D.J Fearon, U O'Sullivan, J.N DUKE-NUS MEDICAL SCHOOL mitochondrial DNA oxygen tumor necrosis factor inhibitor vasculotropin biological product mitochondrial DNA oxygen tumor necrosis factor alpha arthritis article clinical article clinical assessment controlled study human immunohistochemistry inflammation lipid peroxidation mitochondrial genome mutagenesis nucleotide sequence oxidative stress oxygen tension synovitis synovium tissue oxygenation visual analog scale cell hypoxia drug antagonism drug effect genetics mitochondrion mutation oxidative stress reverse transcription polymerase chain reaction rheumatoid arthritis synovium Arthritis, Rheumatoid Biological Agents Cell Hypoxia DNA, Mitochondrial Humans Immunohistochemistry Mitochondria Mutagenesis Mutation Oxidative Stress Oxygen Reverse Transcriptase Polymerase Chain Reaction Synovial Membrane Tumor Necrosis Factor-alpha 10.1186/ar3424 Arthritis Research and Therapy 13 4 R121 2020-10-27T11:31:42Z 2020-10-27T11:31:42Z 2011 Article Biniecka, M, Kennedy, A, Ng, C.T, Chang, T.C, Balogh, E, Fox, E, Veale, D.J, Fearon, U, O'Sullivan, J.N (2011). Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis. Arthritis Research and Therapy 13 (4) : R121. ScholarBank@NUS Repository. https://doi.org/10.1186/ar3424 14786354 https://scholarbank.nus.edu.sg/handle/10635/181630 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	mitochondrial DNA oxygen tumor necrosis factor inhibitor vasculotropin biological product mitochondrial DNA oxygen tumor necrosis factor alpha arthritis article clinical article clinical assessment controlled study human immunohistochemistry inflammation lipid peroxidation mitochondrial genome mutagenesis nucleotide sequence oxidative stress oxygen tension synovitis synovium tissue oxygenation visual analog scale cell hypoxia drug antagonism drug effect genetics mitochondrion mutation oxidative stress reverse transcription polymerase chain reaction rheumatoid arthritis synovium Arthritis, Rheumatoid Biological Agents Cell Hypoxia DNA, Mitochondrial Humans Immunohistochemistry Mitochondria Mutagenesis Mutation Oxidative Stress Oxygen Reverse Transcriptase Polymerase Chain Reaction Synovial Membrane Tumor Necrosis Factor-alpha
spellingShingle	mitochondrial DNA oxygen tumor necrosis factor inhibitor vasculotropin biological product mitochondrial DNA oxygen tumor necrosis factor alpha arthritis article clinical article clinical assessment controlled study human immunohistochemistry inflammation lipid peroxidation mitochondrial genome mutagenesis nucleotide sequence oxidative stress oxygen tension synovitis synovium tissue oxygenation visual analog scale cell hypoxia drug antagonism drug effect genetics mitochondrion mutation oxidative stress reverse transcription polymerase chain reaction rheumatoid arthritis synovium Arthritis, Rheumatoid Biological Agents Cell Hypoxia DNA, Mitochondrial Humans Immunohistochemistry Mitochondria Mutagenesis Mutation Oxidative Stress Oxygen Reverse Transcriptase Polymerase Chain Reaction Synovial Membrane Tumor Necrosis Factor-alpha Biniecka, M Kennedy, A Ng, C.T Chang, T.C Balogh, E Fox, E Veale, D.J Fearon, U O'Sullivan, J.N Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis
description	10.1186/ar3424
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Biniecka, M Kennedy, A Ng, C.T Chang, T.C Balogh, E Fox, E Veale, D.J Fearon, U O'Sullivan, J.N
format	Article
author	Biniecka, M Kennedy, A Ng, C.T Chang, T.C Balogh, E Fox, E Veale, D.J Fearon, U O'Sullivan, J.N
author_sort	Biniecka, M
title	Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis
title_short	Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis
title_full	Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis
title_fullStr	Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis
title_full_unstemmed	Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis
title_sort	successful tumour necrosis factor (tnf) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/181630
_version_	1781792572050505728

Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis

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