High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia

• Main Authors: Tan, B.X, Khoo, K.H, Lim, T.M, Lane, D.P
• Other Authors: BIOLOGY
• Format: Article
• Published: 2020
• Subjects: nutlin 3; protein MDMX; protein p53; imidazole derivative; MDM4 protein, human; nuclear protein; oncoprotein; piperazine derivative; TP53 protein, human; acute granulocytic leukemia; apoptosis; article; cell cycle arrest; cell level; concentration response; controlled study; cytoplasm; drug sensitivity; dynamics; flow cytometry; genetic manipulation; half life time; human; human cell; incubation time; leukemia cell line; protein analysis; protein function; protein localization; protein protein interaction; protein stability; protein synthesis inhibition; transcription termination; wild type; antagonists and inhibitors; drug effects; genetics; Leukemia, Myeloid, Acute; metabolism; pathology; physiology; tumor cell line; Apoptosis; Cell Line, Tumor; Humans; Imidazoles; Nuclear Proteins; Piperazines; Proto-Oncogene Proteins; Tumor Suppressor Protein p53
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181788
• Institution: National University of Singapore

10.18632/oncotarget.1559