High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia

10.18632/oncotarget.1559

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Main Authors:	Tan, B.X, Khoo, K.H, Lim, T.M, Lane, D.P
Other Authors:	BIOLOGY
Format:	Article
Published:	2020
Subjects:	nutlin 3 protein MDMX protein p53 imidazole derivative MDM4 protein, human nuclear protein oncoprotein piperazine derivative TP53 protein, human acute granulocytic leukemia apoptosis article cell cycle arrest cell level concentration response controlled study cytoplasm drug sensitivity dynamics flow cytometry genetic manipulation half life time human human cell incubation time leukemia cell line protein analysis protein function protein localization protein protein interaction protein stability protein synthesis inhibition transcription termination wild type antagonists and inhibitors drug effects genetics Leukemia, Myeloid, Acute metabolism pathology physiology tumor cell line Apoptosis Cell Line, Tumor Humans Imidazoles Nuclear Proteins Piperazines Proto-Oncogene Proteins Tumor Suppressor Protein p53
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/181788
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1817882024-11-10T04:27:04Z High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia Tan, B.X Khoo, K.H Lim, T.M Lane, D.P BIOLOGY MEDICINE nutlin 3 protein MDMX protein p53 imidazole derivative MDM4 protein, human nuclear protein nutlin 3 oncoprotein piperazine derivative protein p53 TP53 protein, human acute granulocytic leukemia apoptosis article cell cycle arrest cell level concentration response controlled study cytoplasm drug sensitivity dynamics flow cytometry genetic manipulation half life time human human cell incubation time leukemia cell line protein analysis protein function protein localization protein protein interaction protein stability protein synthesis inhibition transcription termination wild type antagonists and inhibitors drug effects genetics Leukemia, Myeloid, Acute metabolism pathology physiology tumor cell line Apoptosis Cell Line, Tumor Humans Imidazoles Leukemia, Myeloid, Acute Nuclear Proteins Piperazines Proto-Oncogene Proteins Tumor Suppressor Protein p53 10.18632/oncotarget.1559 Oncotarget 5 4 933-943 2020-10-28T07:14:39Z 2020-10-28T07:14:39Z 2014 Article Tan, B.X, Khoo, K.H, Lim, T.M, Lane, D.P (2014). High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia. Oncotarget 5 (4) : 933-943. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.1559 19492553 https://scholarbank.nus.edu.sg/handle/10635/181788 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	nutlin 3 protein MDMX protein p53 imidazole derivative MDM4 protein, human nuclear protein nutlin 3 oncoprotein piperazine derivative protein p53 TP53 protein, human acute granulocytic leukemia apoptosis article cell cycle arrest cell level concentration response controlled study cytoplasm drug sensitivity dynamics flow cytometry genetic manipulation half life time human human cell incubation time leukemia cell line protein analysis protein function protein localization protein protein interaction protein stability protein synthesis inhibition transcription termination wild type antagonists and inhibitors drug effects genetics Leukemia, Myeloid, Acute metabolism pathology physiology tumor cell line Apoptosis Cell Line, Tumor Humans Imidazoles Leukemia, Myeloid, Acute Nuclear Proteins Piperazines Proto-Oncogene Proteins Tumor Suppressor Protein p53
spellingShingle	nutlin 3 protein MDMX protein p53 imidazole derivative MDM4 protein, human nuclear protein nutlin 3 oncoprotein piperazine derivative protein p53 TP53 protein, human acute granulocytic leukemia apoptosis article cell cycle arrest cell level concentration response controlled study cytoplasm drug sensitivity dynamics flow cytometry genetic manipulation half life time human human cell incubation time leukemia cell line protein analysis protein function protein localization protein protein interaction protein stability protein synthesis inhibition transcription termination wild type antagonists and inhibitors drug effects genetics Leukemia, Myeloid, Acute metabolism pathology physiology tumor cell line Apoptosis Cell Line, Tumor Humans Imidazoles Leukemia, Myeloid, Acute Nuclear Proteins Piperazines Proto-Oncogene Proteins Tumor Suppressor Protein p53 Tan, B.X Khoo, K.H Lim, T.M Lane, D.P High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia
description	10.18632/oncotarget.1559
author2	BIOLOGY
author_facet	BIOLOGY Tan, B.X Khoo, K.H Lim, T.M Lane, D.P
format	Article
author	Tan, B.X Khoo, K.H Lim, T.M Lane, D.P
author_sort	Tan, B.X
title	High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia
title_short	High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia
title_full	High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia
title_fullStr	High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia
title_full_unstemmed	High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia
title_sort	high mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/181788
_version_	1821214942822400000

High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia

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