Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: Rapid reversal by anti-Aß agents

10.1186/s40478-014-0175-x

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Main Authors:	Qi, Y, Klyubin, I, Harney, S.C, Hu, N.W, Cullen, W.K, Grant, M.K, Steffen, J, Wilson, E.N, Do Carmo, S, Remy, S, Fuhrmann, M, Ashe, K.H, Cuello, A.C, Rowan, M.J
Other Authors:	PHARMACOLOGY
Format:	Article
Published:	2020
Subjects:	amyloid beta protein amyloid precursor protein antibody aspartic proteinase Bace protein, rat fused heterocyclic rings MRK 560 N-(3-(2-amino-4a,5,7,7a-tetrahydro-4H-furo(3,4-d)(1,3)thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide picolinic acid derivative secretase sulfonamide age Alzheimer disease animal animal behavior antagonists and inhibitors disease model drug effects genetics hippocampus human immunology long term potentiation male metabolism pathophysiology physiology rat synaptic transmission transgenic rat Wistar rat Age Factors Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Amyloid Precursor Protein Secretases Animals Antibodies Aspartic Acid Endopeptidases Behavior, Animal Disease Models, Animal Heterocyclic Compounds, 2-Ring Hippocampus Humans Long-Term Potentiation Male Picolinic Acids Rats Rats, Transgenic Rats, Wistar Sulfonamides Synaptic Transmission
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/182027
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1820272024-11-15T07:34:26Z Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: Rapid reversal by anti-Aß agents Qi, Y Klyubin, I Harney, S.C Hu, N.W Cullen, W.K Grant, M.K Steffen, J Wilson, E.N Do Carmo, S Remy, S Fuhrmann, M Ashe, K.H Cuello, A.C Rowan, M.J PHARMACOLOGY amyloid beta protein amyloid precursor protein antibody aspartic proteinase Bace protein, rat fused heterocyclic rings MRK 560 N-(3-(2-amino-4a,5,7,7a-tetrahydro-4H-furo(3,4-d)(1,3)thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide picolinic acid derivative secretase sulfonamide age Alzheimer disease animal animal behavior antagonists and inhibitors disease model drug effects genetics hippocampus human immunology long term potentiation male metabolism pathophysiology physiology rat synaptic transmission transgenic rat Wistar rat Age Factors Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Amyloid Precursor Protein Secretases Animals Antibodies Aspartic Acid Endopeptidases Behavior, Animal Disease Models, Animal Heterocyclic Compounds, 2-Ring Hippocampus Humans Long-Term Potentiation Male Picolinic Acids Rats Rats, Transgenic Rats, Wistar Sulfonamides Synaptic Transmission 10.1186/s40478-014-0175-x Acta Neuropathologica Communications 2 1 175 2020-10-30T01:56:39Z 2020-10-30T01:56:39Z 2014 Article Qi, Y, Klyubin, I, Harney, S.C, Hu, N.W, Cullen, W.K, Grant, M.K, Steffen, J, Wilson, E.N, Do Carmo, S, Remy, S, Fuhrmann, M, Ashe, K.H, Cuello, A.C, Rowan, M.J (2014). Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: Rapid reversal by anti-Aß agents. Acta Neuropathologica Communications 2 (1) : 175. ScholarBank@NUS Repository. https://doi.org/10.1186/s40478-014-0175-x 20515960 https://scholarbank.nus.edu.sg/handle/10635/182027 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	amyloid beta protein amyloid precursor protein antibody aspartic proteinase Bace protein, rat fused heterocyclic rings MRK 560 N-(3-(2-amino-4a,5,7,7a-tetrahydro-4H-furo(3,4-d)(1,3)thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide picolinic acid derivative secretase sulfonamide age Alzheimer disease animal animal behavior antagonists and inhibitors disease model drug effects genetics hippocampus human immunology long term potentiation male metabolism pathophysiology physiology rat synaptic transmission transgenic rat Wistar rat Age Factors Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Amyloid Precursor Protein Secretases Animals Antibodies Aspartic Acid Endopeptidases Behavior, Animal Disease Models, Animal Heterocyclic Compounds, 2-Ring Hippocampus Humans Long-Term Potentiation Male Picolinic Acids Rats Rats, Transgenic Rats, Wistar Sulfonamides Synaptic Transmission
spellingShingle	amyloid beta protein amyloid precursor protein antibody aspartic proteinase Bace protein, rat fused heterocyclic rings MRK 560 N-(3-(2-amino-4a,5,7,7a-tetrahydro-4H-furo(3,4-d)(1,3)thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide picolinic acid derivative secretase sulfonamide age Alzheimer disease animal animal behavior antagonists and inhibitors disease model drug effects genetics hippocampus human immunology long term potentiation male metabolism pathophysiology physiology rat synaptic transmission transgenic rat Wistar rat Age Factors Alzheimer Disease Amyloid beta-Peptides Amyloid beta-Protein Precursor Amyloid Precursor Protein Secretases Animals Antibodies Aspartic Acid Endopeptidases Behavior, Animal Disease Models, Animal Heterocyclic Compounds, 2-Ring Hippocampus Humans Long-Term Potentiation Male Picolinic Acids Rats Rats, Transgenic Rats, Wistar Sulfonamides Synaptic Transmission Qi, Y Klyubin, I Harney, S.C Hu, N.W Cullen, W.K Grant, M.K Steffen, J Wilson, E.N Do Carmo, S Remy, S Fuhrmann, M Ashe, K.H Cuello, A.C Rowan, M.J Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: Rapid reversal by anti-Aß agents
description	10.1186/s40478-014-0175-x
author2	PHARMACOLOGY
author_facet	PHARMACOLOGY Qi, Y Klyubin, I Harney, S.C Hu, N.W Cullen, W.K Grant, M.K Steffen, J Wilson, E.N Do Carmo, S Remy, S Fuhrmann, M Ashe, K.H Cuello, A.C Rowan, M.J
format	Article
author	Qi, Y Klyubin, I Harney, S.C Hu, N.W Cullen, W.K Grant, M.K Steffen, J Wilson, E.N Do Carmo, S Remy, S Fuhrmann, M Ashe, K.H Cuello, A.C Rowan, M.J
author_sort	Qi, Y
title	Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: Rapid reversal by anti-Aß agents
title_short	Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: Rapid reversal by anti-Aß agents
title_full	Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: Rapid reversal by anti-Aß agents
title_fullStr	Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: Rapid reversal by anti-Aß agents
title_full_unstemmed	Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: Rapid reversal by anti-Aß agents
title_sort	longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-aß agents
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/182027
_version_	1821185988892819456

Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: Rapid reversal by anti-Aß agents

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