Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: Rapid reversal by anti-Aß agents

• Main Authors: Qi, Y, Klyubin, I, Harney, S.C, Hu, N.W, Cullen, W.K, Grant, M.K, Steffen, J, Wilson, E.N, Do Carmo, S, Remy, S, Fuhrmann, M, Ashe, K.H, Cuello, A.C, Rowan, M.J
• Other Authors: DEPT OF PHARMACOLOGY
• Format: Article
• Published: 2020
• Subjects: amyloid beta protein; amyloid precursor protein; antibody; aspartic proteinase; Bace protein, rat; fused heterocyclic rings; MRK 560; N-(3-(2-amino-4a,5,7,7a-tetrahydro-4H-furo(3,4-d)(1,3)thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide; picolinic acid derivative; secretase; sulfonamide; age; Alzheimer disease; animal; animal behavior; antagonists and inhibitors; disease model; drug effects; genetics; hippocampus; human; immunology; long term potentiation; male; metabolism; pathophysiology; physiology; rat; synaptic transmission; transgenic rat; Wistar rat; Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Antibodies; Aspartic Acid Endopeptidases; Behavior, Animal; Disease Models, Animal; Heterocyclic Compounds, 2-Ring; Hippocampus; Humans; Long-Term Potentiation; Male; Picolinic Acids; Rats; Rats, Transgenic; Rats, Wistar; Sulfonamides; Synaptic Transmission
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/182027
• Institution: National University of Singapore

10.1186/s40478-014-0175-x