A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria

• Main Authors: Murima, P, Zimmermann, M, Chopra, T, Pojer, F, Fonti, G, Dal Peraro, M, Alonso, S, Sauer, U, Pethe, K, McKinney, J.D
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: carbon; glyoxylic acid; isocitrate lyase; bacterial protein; fatty acid; glyoxylic acid derivative; isocitrate dehydrogenase; bifurcation; carbon flux; chemotherapy; coliform bacterium; enzyme activity; infectivity; metabolism; partitioning; pathogenicity; steady-state equilibrium; tuberculosis; allosterism; Article; bacterial growth; bacterial strain; biosynthesis; carbon source; citric acid cycle; controlled study; energy metabolism; energy yield; enzyme phosphorylation; Escherichia coli; fatty acid metabolism; Mycobacterium tuberculosis; nonhuman; regulatory mechanism; biological model; carbon cycle; classification; kinetics; Mycobacterium; species difference; Corynebacterineae; Bacterial Proteins; Carbon; Carbon Cycle; Citric Acid Cycle; Fatty Acids; Glyoxylates; Isocitrate Dehydrogenase; Isocitrate Lyase; Kinetics; Models, Biological; Species Specificity
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/182436
• Institution: National University of Singapore

10.1038/ncomms12527