Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis

• Main Authors: Mencarelli, A, Cipriani, S, Francisci, D, Santucci, L, Baldelli, F, Distrutti, E, Fiorucci, S
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: CD11b antigen; chemokine; cyclohexane derivative; dextran sulfate; homeodomain protein; maraviroc; RAG-1 protein; RANTES; triazole derivative; trinitrobenzenesulfonic acid; animal; antagonists and inhibitors; C57BL mouse; CD4+ T lymphocyte; chemically induced; colitis; colon; cytology; disease model; drug effects; genetics; immunology; inflammation; intestine mucosa; knockout mouse; leukocyte; metabolism; mouse; pathology; physiology; Th17 cell; transplantation; upregulation; Animals; CD11b Antigen; CD4-Positive T-Lymphocytes; Chemokine CCL5; Chemokines; Colitis; Colon; Cyclohexanes; Dextran Sulfate; Disease Models, Animal; Homeodomain Proteins; Inflammation; Intestinal Mucosa; Leukocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Th17 Cells; Triazoles; Trinitrobenzenesulfonic Acid; Up-Regulation
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/182439
• Institution: National University of Singapore

10.1038/srep30802