Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis

10.1038/srep30802

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Main Authors:	Mencarelli, A, Cipriani, S, Francisci, D, Santucci, L, Baldelli, F, Distrutti, E, Fiorucci, S
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	CD11b antigen chemokine cyclohexane derivative dextran sulfate homeodomain protein maraviroc RAG-1 protein RANTES triazole derivative trinitrobenzenesulfonic acid animal antagonists and inhibitors C57BL mouse CD4+ T lymphocyte chemically induced colitis colon cytology disease model drug effects genetics immunology inflammation intestine mucosa knockout mouse leukocyte metabolism mouse pathology physiology Th17 cell transplantation upregulation Animals CD11b Antigen CD4-Positive T-Lymphocytes Chemokine CCL5 Chemokines Colitis Colon Cyclohexanes Dextran Sulfate Disease Models, Animal Homeodomain Proteins Inflammation Intestinal Mucosa Leukocytes Mice Mice, Inbred C57BL Mice, Knockout Th17 Cells Triazoles Trinitrobenzenesulfonic Acid Up-Regulation
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/182439
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Institution:	National University of Singapore

id	sg-nus-scholar.10635-182439
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spelling	sg-nus-scholar.10635-1824392023-10-31T20:58:01Z Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis Mencarelli, A Cipriani, S Francisci, D Santucci, L Baldelli, F Distrutti, E Fiorucci, S DUKE-NUS MEDICAL SCHOOL CD11b antigen chemokine cyclohexane derivative dextran sulfate homeodomain protein maraviroc RAG-1 protein RANTES triazole derivative trinitrobenzenesulfonic acid animal antagonists and inhibitors C57BL mouse CD4+ T lymphocyte chemically induced colitis colon cytology disease model drug effects genetics immunology inflammation intestine mucosa knockout mouse leukocyte metabolism mouse pathology physiology Th17 cell transplantation upregulation Animals CD11b Antigen CD4-Positive T-Lymphocytes Chemokine CCL5 Chemokines Colitis Colon Cyclohexanes Dextran Sulfate Disease Models, Animal Homeodomain Proteins Inflammation Intestinal Mucosa Leukocytes Mice Mice, Inbred C57BL Mice, Knockout Th17 Cells Triazoles Trinitrobenzenesulfonic Acid Up-Regulation 10.1038/srep30802 Scientific Reports 6 30802 2020-10-31T11:28:35Z 2020-10-31T11:28:35Z 2016 Article Mencarelli, A, Cipriani, S, Francisci, D, Santucci, L, Baldelli, F, Distrutti, E, Fiorucci, S (2016). Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis. Scientific Reports 6 : 30802. ScholarBank@NUS Repository. https://doi.org/10.1038/srep30802 2045-2322 https://scholarbank.nus.edu.sg/handle/10635/182439 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Publishing Group Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	CD11b antigen chemokine cyclohexane derivative dextran sulfate homeodomain protein maraviroc RAG-1 protein RANTES triazole derivative trinitrobenzenesulfonic acid animal antagonists and inhibitors C57BL mouse CD4+ T lymphocyte chemically induced colitis colon cytology disease model drug effects genetics immunology inflammation intestine mucosa knockout mouse leukocyte metabolism mouse pathology physiology Th17 cell transplantation upregulation Animals CD11b Antigen CD4-Positive T-Lymphocytes Chemokine CCL5 Chemokines Colitis Colon Cyclohexanes Dextran Sulfate Disease Models, Animal Homeodomain Proteins Inflammation Intestinal Mucosa Leukocytes Mice Mice, Inbred C57BL Mice, Knockout Th17 Cells Triazoles Trinitrobenzenesulfonic Acid Up-Regulation
spellingShingle	CD11b antigen chemokine cyclohexane derivative dextran sulfate homeodomain protein maraviroc RAG-1 protein RANTES triazole derivative trinitrobenzenesulfonic acid animal antagonists and inhibitors C57BL mouse CD4+ T lymphocyte chemically induced colitis colon cytology disease model drug effects genetics immunology inflammation intestine mucosa knockout mouse leukocyte metabolism mouse pathology physiology Th17 cell transplantation upregulation Animals CD11b Antigen CD4-Positive T-Lymphocytes Chemokine CCL5 Chemokines Colitis Colon Cyclohexanes Dextran Sulfate Disease Models, Animal Homeodomain Proteins Inflammation Intestinal Mucosa Leukocytes Mice Mice, Inbred C57BL Mice, Knockout Th17 Cells Triazoles Trinitrobenzenesulfonic Acid Up-Regulation Mencarelli, A Cipriani, S Francisci, D Santucci, L Baldelli, F Distrutti, E Fiorucci, S Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis
description	10.1038/srep30802
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Mencarelli, A Cipriani, S Francisci, D Santucci, L Baldelli, F Distrutti, E Fiorucci, S
format	Article
author	Mencarelli, A Cipriani, S Francisci, D Santucci, L Baldelli, F Distrutti, E Fiorucci, S
author_sort	Mencarelli, A
title	Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis
title_short	Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis
title_full	Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis
title_fullStr	Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis
title_full_unstemmed	Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis
title_sort	highly specific blockade of ccr5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/182439
_version_	1781792599315578880

Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis

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