Maintenance of the functional integrity of mouse hematopoiesis by EED and promotion of leukemogenesis by EED haploinsufficiency

• Main Authors: Ikeda, K, Ueda, T, Yamasaki, N, Nakata, Y, Sera, Y, Nagamachi, A, Miyama, T, Kobayashi, H, Takubo, K, Kanai, A, Oda, H, Wolff, L, Honda, Z.-I, Ichinohe, T, Matsubara, A, Suda, T, Inaba, T, Honda, H
• Other Authors: MEDICINE
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: CD34 antigen; Eed protein, mouse; fibronectin; histone; polycomb repressive complex 2; small interfering RNA; animal; C57BL mouse; cell adhesion; cell cycle; cell differentiation; cell proliferation; cell transformation; chemistry; cytology; extracellular matrix; female; fetus blood; flow cytometry; gene transfer; genetics; haploinsufficiency; hematologic disease; hematopoiesis; hematopoietic stem cell; heterozygote; leukemia; male; metabolism; mouse; physiology; Animals; Antigens, CD34; Cell Adhesion; Cell Cycle; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Extracellular Matrix; Female; Fetal Blood; Fibronectins; Flow Cytometry; Gene Transfer Techniques; Haploinsufficiency; Hematologic Neoplasms; Hematopoiesis; Hematopoietic Stem Cells; Heterozygote; Histones; Leukemia; Male; Mice; Mice, Inbred C57BL; Polycomb Repressive Complex 2; RNA, Small Interfering
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/182444
• Institution: National University of Singapore

10.1038/srep29454