Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells

• Main Authors: Baptista, M.A.P, Keszei, M, Oliveira, M, Sunahara, K.K.S, Andersson, J, Dahlberg, C.I.M, Worth, A.J, Liedén, A, Kuo, I.-C, Wallin, R.P.A, Snapper, S.B, Eidsmo, L, Scheynius, A, Karlsson, M.C.I, Bouma, G, Burns, S.O, Forsell, M.N.E, Thrasher, A.J, Nylén, S, Westerberg, L.S
• Other Authors: PAEDIATRICS
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: gamma interferon; Rac2 protein; reactive oxygen metabolite; Wiskott Aldrich syndrome protein; arthropod protein; Dermatophagoides pteronyssinus antigen p 2; house dust allergen; Rac protein; cells and cell components; disease; enzyme; enzyme activity; gene; mutation; pH; protein; animal cell; animal experiment; animal model; animal tissue; Article; CD4+ T lymphocyte; CD8+ T lymphocyte; cell expansion; controlled study; cross presentation; dendritic cell; enzyme activation; female; gene deletion; gene expression; intracellular signaling; lymphatic drainage; male; mouse; nonhuman; phagosome; protein function; spleen; animal; Bagg albino mouse; C57BL mouse; cell proliferation; chemistry; deficiency; immunology; knockout mouse; Leishmania major; lymphocyte count; metabolism; parasitology; pathology; physiology; protein domain; skin; Mus; Animals; Antigens, Dermatophagoides; Arthropod Proteins; CD8-Positive T-Lymphocytes; Cell Proliferation; Cross-Priming; Dendritic Cells; Gene Deletion; Interferon-gamma; Lymphocyte Count; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Phagosomes; Protein Domains; rac GTP-Binding Proteins; Reactive Oxygen Species; Skin; Wiskott-Aldrich Syndrome Protein
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/182446
• Institution: National University of Singapore

10.1038/ncomms12175