Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

• المؤلفون الرئيسيون: Chattopadhyay, A, O'Connor, C.J, Zhang, F, Galvagnion, C, Galloway, W.R.J.D, Tan, Y.S, Stokes, J.E, Rahman, T, Verma, C, Spring, D.R, Itzhaki, L.S
• مؤلفون آخرون: BIOLOGY
• التنسيق: مقال
• منشور في: Nature Publishing Group 2020
• الموضوعات: antineoplastic agent; AURKA protein, human; aurora A kinase; benzenesulfonic acid derivative; cell cycle protein; cjoc42 compound; microtubule associated protein; nuclear protein; oncoprotein; proteasome; protein p53; PSMD10 protein, human; Rad51 protein; TP53 protein, human; TPX2 protein, human; triazole derivative; calorimetry; cell survival; chemistry; DNA damage; Escherichia coli; gene expression profiling; gene expression regulation; human; mass spectrometry; metabolism; neoplasm; nuclear magnetic resonance spectroscopy; thermodynamics; tumor cell line; Antineoplastic Agents; Aurora Kinase A; Benzenesulfonates; Calorimetry; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; DNA Damage; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microtubule-Associated Proteins; Neoplasms; Nuclear Proteins; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Rad51 Recombinase; Thermodynamics; Triazoles; Tumor Suppressor Protein p53
• الوصول للمادة أونلاين: https://scholarbank.nus.edu.sg/handle/10635/182485

10.1038/srep23732