Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

10.1038/srep23732

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Main Authors:	Chattopadhyay, A, O'Connor, C.J, Zhang, F, Galvagnion, C, Galloway, W.R.J.D, Tan, Y.S, Stokes, J.E, Rahman, T, Verma, C, Spring, D.R, Itzhaki, L.S
Other Authors:	BIOLOGY (NU)
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	antineoplastic agent AURKA protein, human aurora A kinase benzenesulfonic acid derivative cell cycle protein cjoc42 compound microtubule associated protein nuclear protein oncoprotein proteasome protein p53 PSMD10 protein, human Rad51 protein TP53 protein, human TPX2 protein, human triazole derivative calorimetry cell survival chemistry DNA damage Escherichia coli gene expression profiling gene expression regulation human mass spectrometry metabolism neoplasm nuclear magnetic resonance spectroscopy thermodynamics tumor cell line Antineoplastic Agents Aurora Kinase A Benzenesulfonates Calorimetry Cell Cycle Proteins Cell Line, Tumor Cell Survival DNA Damage Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Magnetic Resonance Spectroscopy Mass Spectrometry Microtubule-Associated Proteins Neoplasms Nuclear Proteins Proteasome Endopeptidase Complex Proto-Oncogene Proteins Rad51 Recombinase Thermodynamics Triazoles Tumor Suppressor Protein p53
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/182485
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1824852023-11-01T07:34:55Z Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell Chattopadhyay, A O'Connor, C.J Zhang, F Galvagnion, C Galloway, W.R.J.D Tan, Y.S Stokes, J.E Rahman, T Verma, C Spring, D.R Itzhaki, L.S BIOLOGY (NU) antineoplastic agent AURKA protein, human aurora A kinase benzenesulfonic acid derivative cell cycle protein cjoc42 compound microtubule associated protein nuclear protein oncoprotein proteasome protein p53 PSMD10 protein, human Rad51 protein TP53 protein, human TPX2 protein, human triazole derivative calorimetry cell survival chemistry DNA damage Escherichia coli gene expression profiling gene expression regulation human mass spectrometry metabolism neoplasm nuclear magnetic resonance spectroscopy thermodynamics tumor cell line Antineoplastic Agents Aurora Kinase A Benzenesulfonates Calorimetry Cell Cycle Proteins Cell Line, Tumor Cell Survival DNA Damage Escherichia coli Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Magnetic Resonance Spectroscopy Mass Spectrometry Microtubule-Associated Proteins Neoplasms Nuclear Proteins Proteasome Endopeptidase Complex Proto-Oncogene Proteins Rad51 Recombinase Thermodynamics Triazoles Tumor Suppressor Protein p53 10.1038/srep23732 Scientific Reports 6 23732 2020-10-31T11:37:08Z 2020-10-31T11:37:08Z 2016 Article Chattopadhyay, A, O'Connor, C.J, Zhang, F, Galvagnion, C, Galloway, W.R.J.D, Tan, Y.S, Stokes, J.E, Rahman, T, Verma, C, Spring, D.R, Itzhaki, L.S (2016). Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell. Scientific Reports 6 : 23732. ScholarBank@NUS Repository. https://doi.org/10.1038/srep23732 2045-2322 https://scholarbank.nus.edu.sg/handle/10635/182485 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Publishing Group Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	antineoplastic agent AURKA protein, human aurora A kinase benzenesulfonic acid derivative cell cycle protein cjoc42 compound microtubule associated protein nuclear protein oncoprotein proteasome protein p53 PSMD10 protein, human Rad51 protein TP53 protein, human TPX2 protein, human triazole derivative calorimetry cell survival chemistry DNA damage Escherichia coli gene expression profiling gene expression regulation human mass spectrometry metabolism neoplasm nuclear magnetic resonance spectroscopy thermodynamics tumor cell line Antineoplastic Agents Aurora Kinase A Benzenesulfonates Calorimetry Cell Cycle Proteins Cell Line, Tumor Cell Survival DNA Damage Escherichia coli Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Magnetic Resonance Spectroscopy Mass Spectrometry Microtubule-Associated Proteins Neoplasms Nuclear Proteins Proteasome Endopeptidase Complex Proto-Oncogene Proteins Rad51 Recombinase Thermodynamics Triazoles Tumor Suppressor Protein p53
spellingShingle	antineoplastic agent AURKA protein, human aurora A kinase benzenesulfonic acid derivative cell cycle protein cjoc42 compound microtubule associated protein nuclear protein oncoprotein proteasome protein p53 PSMD10 protein, human Rad51 protein TP53 protein, human TPX2 protein, human triazole derivative calorimetry cell survival chemistry DNA damage Escherichia coli gene expression profiling gene expression regulation human mass spectrometry metabolism neoplasm nuclear magnetic resonance spectroscopy thermodynamics tumor cell line Antineoplastic Agents Aurora Kinase A Benzenesulfonates Calorimetry Cell Cycle Proteins Cell Line, Tumor Cell Survival DNA Damage Escherichia coli Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Magnetic Resonance Spectroscopy Mass Spectrometry Microtubule-Associated Proteins Neoplasms Nuclear Proteins Proteasome Endopeptidase Complex Proto-Oncogene Proteins Rad51 Recombinase Thermodynamics Triazoles Tumor Suppressor Protein p53 Chattopadhyay, A O'Connor, C.J Zhang, F Galvagnion, C Galloway, W.R.J.D Tan, Y.S Stokes, J.E Rahman, T Verma, C Spring, D.R Itzhaki, L.S Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell
description	10.1038/srep23732
author2	BIOLOGY (NU)
author_facet	BIOLOGY (NU) Chattopadhyay, A O'Connor, C.J Zhang, F Galvagnion, C Galloway, W.R.J.D Tan, Y.S Stokes, J.E Rahman, T Verma, C Spring, D.R Itzhaki, L.S
format	Article
author	Chattopadhyay, A O'Connor, C.J Zhang, F Galvagnion, C Galloway, W.R.J.D Tan, Y.S Stokes, J.E Rahman, T Verma, C Spring, D.R Itzhaki, L.S
author_sort	Chattopadhyay, A
title	Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell
title_short	Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell
title_full	Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell
title_fullStr	Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell
title_full_unstemmed	Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell
title_sort	discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/182485
_version_	1781792610065580032

Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

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