The KDM3A-KLF2-IRF4 axis maintains myeloma cell survival

• Main Authors: Ohguchi, H, Hideshima, T, Bhasin, M.K, Gorgun, G.T, Santo, L, Cea, M, Samur, M.K, Mimura, N, Suzuki, R, Tai, Y.-T, Carrasco, R.D, Raje, N, Richardson, P.G, Munshi, N.C, Harigae, H, Sanda, T, Sakai, J, Anderson, K.C
• Other Authors: MEDICINE
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: caspase 7; caspase 8; histone demethylase; histone H3; interferon regulatory factor 4; kruppel like factor 2; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; protein KDM3A; unclassified drug; histone; interferon regulatory factor; interferon regulatory factor-4; KDM3A protein, human; KLF2 protein, human; kruppel like factor; anatomy; apoptosis; bone; cells and cell components; gene expression; tumor; animal cell; animal experiment; animal model; animal tissue; Article; autoregulation; bone marrow; bone marrow stroma cell; cell adhesion; cell homing; cell interaction; cell survival; controlled study; gene silencing; histone demethylation; human; human cell; immunoblotting; in vitro study; in vivo study; male; microarray analysis; monoclonal immunoglobulinemia; mouse; multiple myeloma; myeloma cell; nonhuman; transactivation; upregulation; cell motion; gene expression regulation; genetics; metabolism; physiology; tumor cell line; Cell Adhesion; Cell Line, Tumor; Cell Movement; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Histones; Humans; Interferon Regulatory Factors; Jumonji Domain-Containing Histone Demethylases; Kruppel-Like Transcription Factors; Multiple Myeloma
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/182516
• Institution: National University of Singapore

10.1038/ncomms10258