BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A

10.1186/bcr2354

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Main Authors:	Puppe, J, Drost, R, Liu, X, Joosse, S.A, Evers, B, Cornelissen-Steijger, P, Nederlof, P, Yu, Q, Jonkers, J, van Lohuizen, M, Pietersen, A.M
Other Authors:	PHYSIOLOGY
Format:	Article
Published:	2020
Subjects:	3 deazaneplanocin A BRCA1 protein transcription factor EZH2 3 deazaneplanocin 3-deazaneplanocin adenosine BRCA1 protein, human drug derivative Ezh2 protein, mouse histone lysine methyltransferase hybrid protein messenger RNA RNA small interfering RNA animal cell animal experiment animal model article breast cancer cancer cell culture cancer inhibition cell differentiation controlled study drug sensitivity gene mutation gene overexpression gene repression genetic analysis heterozygote human human tissue immunohistochemistry mouse nonhuman phenotype protein expression animal biosynthesis breast tumor DNA repair drug antagonism drug delivery system drug effect female gene silencing genetics metabolism mutation pathology physiology tumor cell line tumor suppressor gene Adenosine Animals BRCA1 Protein Breast Neoplasms Cell Line, Tumor DNA Repair Drug Delivery Systems Female Gene Knockdown Techniques Genes, BRCA1 Histone-Lysine N-Methyltransferase Humans Mice Mutation Recombinant Fusion Proteins RNA, Messenger RNA, Neoplasm RNA, Small Interfering
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/183273
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1832732024-04-04T01:10:41Z BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A Puppe, J Drost, R Liu, X Joosse, S.A Evers, B Cornelissen-Steijger, P Nederlof, P Yu, Q Jonkers, J van Lohuizen, M Pietersen, A.M PHYSIOLOGY 3 deazaneplanocin A BRCA1 protein transcription factor EZH2 3 deazaneplanocin 3-deazaneplanocin adenosine BRCA1 protein BRCA1 protein, human drug derivative Ezh2 protein, mouse histone lysine methyltransferase hybrid protein messenger RNA RNA small interfering RNA animal cell animal experiment animal model article breast cancer cancer cell culture cancer inhibition cell differentiation controlled study drug sensitivity gene mutation gene overexpression gene repression genetic analysis heterozygote human human tissue immunohistochemistry mouse nonhuman phenotype protein expression animal biosynthesis breast tumor DNA repair drug antagonism drug delivery system drug effect female gene silencing genetics metabolism mutation pathology physiology tumor cell line tumor suppressor gene Adenosine Animals BRCA1 Protein Breast Neoplasms Cell Line, Tumor DNA Repair Drug Delivery Systems Female Gene Knockdown Techniques Genes, BRCA1 Histone-Lysine N-Methyltransferase Humans Mice Mutation Recombinant Fusion Proteins RNA, Messenger RNA, Neoplasm RNA, Small Interfering 10.1186/bcr2354 Breast Cancer Research 11 4 R63 2020-11-10T00:43:28Z 2020-11-10T00:43:28Z 2009 Article Puppe, J, Drost, R, Liu, X, Joosse, S.A, Evers, B, Cornelissen-Steijger, P, Nederlof, P, Yu, Q, Jonkers, J, van Lohuizen, M, Pietersen, A.M (2009). BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A. Breast Cancer Research 11 (4) : R63. ScholarBank@NUS Repository. https://doi.org/10.1186/bcr2354 14655411 https://scholarbank.nus.edu.sg/handle/10635/183273 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	3 deazaneplanocin A BRCA1 protein transcription factor EZH2 3 deazaneplanocin 3-deazaneplanocin adenosine BRCA1 protein BRCA1 protein, human drug derivative Ezh2 protein, mouse histone lysine methyltransferase hybrid protein messenger RNA RNA small interfering RNA animal cell animal experiment animal model article breast cancer cancer cell culture cancer inhibition cell differentiation controlled study drug sensitivity gene mutation gene overexpression gene repression genetic analysis heterozygote human human tissue immunohistochemistry mouse nonhuman phenotype protein expression animal biosynthesis breast tumor DNA repair drug antagonism drug delivery system drug effect female gene silencing genetics metabolism mutation pathology physiology tumor cell line tumor suppressor gene Adenosine Animals BRCA1 Protein Breast Neoplasms Cell Line, Tumor DNA Repair Drug Delivery Systems Female Gene Knockdown Techniques Genes, BRCA1 Histone-Lysine N-Methyltransferase Humans Mice Mutation Recombinant Fusion Proteins RNA, Messenger RNA, Neoplasm RNA, Small Interfering
spellingShingle	3 deazaneplanocin A BRCA1 protein transcription factor EZH2 3 deazaneplanocin 3-deazaneplanocin adenosine BRCA1 protein BRCA1 protein, human drug derivative Ezh2 protein, mouse histone lysine methyltransferase hybrid protein messenger RNA RNA small interfering RNA animal cell animal experiment animal model article breast cancer cancer cell culture cancer inhibition cell differentiation controlled study drug sensitivity gene mutation gene overexpression gene repression genetic analysis heterozygote human human tissue immunohistochemistry mouse nonhuman phenotype protein expression animal biosynthesis breast tumor DNA repair drug antagonism drug delivery system drug effect female gene silencing genetics metabolism mutation pathology physiology tumor cell line tumor suppressor gene Adenosine Animals BRCA1 Protein Breast Neoplasms Cell Line, Tumor DNA Repair Drug Delivery Systems Female Gene Knockdown Techniques Genes, BRCA1 Histone-Lysine N-Methyltransferase Humans Mice Mutation Recombinant Fusion Proteins RNA, Messenger RNA, Neoplasm RNA, Small Interfering Puppe, J Drost, R Liu, X Joosse, S.A Evers, B Cornelissen-Steijger, P Nederlof, P Yu, Q Jonkers, J van Lohuizen, M Pietersen, A.M BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A
description	10.1186/bcr2354
author2	PHYSIOLOGY
author_facet	PHYSIOLOGY Puppe, J Drost, R Liu, X Joosse, S.A Evers, B Cornelissen-Steijger, P Nederlof, P Yu, Q Jonkers, J van Lohuizen, M Pietersen, A.M
format	Article
author	Puppe, J Drost, R Liu, X Joosse, S.A Evers, B Cornelissen-Steijger, P Nederlof, P Yu, Q Jonkers, J van Lohuizen, M Pietersen, A.M
author_sort	Puppe, J
title	BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A
title_short	BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A
title_full	BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A
title_fullStr	BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A
title_full_unstemmed	BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A
title_sort	brca1-deficient mammary tumor cells are dependent on ezh2 expression and sensitive to polycomb repressive complex 2-inhibitor 3-deazaneplanocin a
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/183273
_version_	1795374596048814080

BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A

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