BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A

BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A

10.1186/bcr2354

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Bibliographic Details
Main Authors:	Puppe, J, Drost, R, Liu, X, Joosse, S.A, Evers, B, Cornelissen-Steijger, P, Nederlof, P, Yu, Q, Jonkers, J, van Lohuizen, M, Pietersen, A.M
Other Authors:	PHYSIOLOGY
Format:	Article
Published:	2020
Subjects:	3 deazaneplanocin A BRCA1 protein transcription factor EZH2 3 deazaneplanocin 3-deazaneplanocin adenosine BRCA1 protein, human drug derivative Ezh2 protein, mouse histone lysine methyltransferase hybrid protein messenger RNA RNA small interfering RNA animal cell animal experiment animal model article breast cancer cancer cell culture cancer inhibition cell differentiation controlled study drug sensitivity gene mutation gene overexpression gene repression genetic analysis heterozygote human human tissue immunohistochemistry mouse nonhuman phenotype protein expression animal biosynthesis breast tumor DNA repair drug antagonism drug delivery system drug effect female gene silencing genetics metabolism mutation pathology physiology tumor cell line tumor suppressor gene Adenosine Animals BRCA1 Protein Breast Neoplasms Cell Line, Tumor DNA Repair Drug Delivery Systems Female Gene Knockdown Techniques Genes, BRCA1 Histone-Lysine N-Methyltransferase Humans Mice Mutation Recombinant Fusion Proteins RNA, Messenger RNA, Neoplasm RNA, Small Interfering
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/183273
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Institution:	National University of Singapore

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