Deletion of nuoG from the vaccine candidate Mycobacterium bovis BCG ΔureC:: Hly improves protection against tuberculosis

• Main Authors: Gengenbacher, M, Nieuwenhuizen, N, Vogelzang, A, Liu, H, Kaiser, P, Schuerer, S, Lazar, D, Wagner, I, Mollenkopf, H.-J, Kaufmann, S.H.E
• Other Authors: MEDICINE
• Format: Article
• Published: 2020
• Subjects: BCG vaccine; cell protein; guanosine triphosphatase; immunoglobulin G; inflammasome; interleukin 18; LC3 protein; transcriptome; ubiquilin protein; unclassified drug; bacterial protein; reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone); animal cell; animal experiment; animal model; animal tissue; apoptosis; Article; B lymphocyte; bacterial gene; bacterial load; BCG vaccination; CD4+ T lymphocyte; cell activation; cell differentiation; controlled study; drug efficacy; drug safety; Gbps gene; gene; gene deletion; gene expression regulation; genetic analysis; helper cell; Ifi204 gene; IL 18 gene; IL 1beta gene; immune response; immunocompetent cell; in vitro study; inflammation; lung tuberculosis; mouse; nonhuman; nuoG gene; priority journal; protein localization; transcriptome analysis; tuberculosis; upregulation; animal; gene expression profiling; genetics; immunology; lung; lymph node; microbiology; Mycobacterium bovis; pathology; Tuberculosis, Pulmonary; vaccination; Animals; Bacterial Load; Bacterial Proteins; BCG Vaccine; Electron Transport Complex I; Gene Deletion; Gene Expression Profiling; Inflammasomes; Lung; Lymph Nodes; Mice; Vaccination
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/183721
• Institution: National University of Singapore

10.1128/mBio.00679-16