Arthroprotective effects of Cf-02 sharing structural similarity with quercetin

• Main Authors: Liu, F.-C, Lu, J.-W, Chien, C.-Y, Huang, H.-S, Lee, C.-C, Lien, S.-B, Lin, L.-C, Chen, L.W, Ho, Y.-J, Shen, M.-C, Ho, L.-J, Lai, J.-H
• Other Authors: BIOLOGICAL SCIENCES
• Format: Article
• Published: MDPI 2020
• Subjects: 6 (2,4 difluorophenyl) 3 (3 (trifluoromethyl)phenyl) 2h benzo[e][1,3]oxazine 2,4(3h) dione; aggrecan; benzamide derivative; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; interferon regulatory factor 1; matrix metalloproteinase; proteoglycan; quercetin; STAT3 protein; transcription factor AP 1; tumor necrosis factor; unclassified drug; collagen; collagenase 3; nitric oxide; protective agent; transcription factor; animal cell; animal model; animal tissue; antiinflammatory activity; arthritis; Article; chondrocyte; comparative molecular similarity indices analysis; controlled study; enzyme activity; gel mobility shift assay; human; human cell; IC50; immunohistochemistry; immunomodulation; MTT assay; nonhuman; pig; protein degradation; protein expression; rat; reverse transcription polymerase chain reaction; signal transduction; Western blotting; animal; chemistry; drug effect; metabolism; pathology; structure activity relation; Animals; Arthritis; Chondrocytes; Collagen; Immunomodulation; Matrix Metalloproteinase 13; Nitric Oxide; Nitric Oxide Synthase Type II; Protective Agents; Proteoglycans; Quercetin; Structure-Activity Relationship; Swine; Transcription Factors; Tumor Necrosis Factor-alpha
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/183845
• Institution: National University of Singapore

10.3390/ijms19051453