Arthroprotective effects of Cf-02 sharing structural similarity with quercetin

10.3390/ijms19051453

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Main Authors:	Liu, F.-C, Lu, J.-W, Chien, C.-Y, Huang, H.-S, Lee, C.-C, Lien, S.-B, Lin, L.-C, Chen, L.W, Ho, Y.-J, Shen, M.-C, Ho, L.-J, Lai, J.-H
Other Authors:	BIOLOGICAL SCIENCES
Format:	Article
Published:	MDPI 2020
Subjects:	6 (2,4 difluorophenyl) 3 (3 (trifluoromethyl)phenyl) 2h benzo[e][1,3]oxazine 2,4(3h) dione aggrecan benzamide derivative immunoglobulin enhancer binding protein inducible nitric oxide synthase interferon regulatory factor 1 matrix metalloproteinase proteoglycan quercetin STAT3 protein transcription factor AP 1 tumor necrosis factor unclassified drug collagen collagenase 3 nitric oxide protective agent transcription factor animal cell animal model animal tissue antiinflammatory activity arthritis Article chondrocyte comparative molecular similarity indices analysis controlled study enzyme activity gel mobility shift assay human human cell IC50 immunohistochemistry immunomodulation MTT assay nonhuman pig protein degradation protein expression rat reverse transcription polymerase chain reaction signal transduction Western blotting animal chemistry drug effect metabolism pathology structure activity relation Animals Arthritis Chondrocytes Collagen Immunomodulation Matrix Metalloproteinase 13 Nitric Oxide Nitric Oxide Synthase Type II Protective Agents Proteoglycans Quercetin Structure-Activity Relationship Swine Transcription Factors Tumor Necrosis Factor-alpha
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/183845
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1838452024-04-03T10:35:38Z Arthroprotective effects of Cf-02 sharing structural similarity with quercetin Liu, F.-C Lu, J.-W Chien, C.-Y Huang, H.-S Lee, C.-C Lien, S.-B Lin, L.-C Chen, L.W Ho, Y.-J Shen, M.-C Ho, L.-J Lai, J.-H BIOLOGICAL SCIENCES 6 (2,4 difluorophenyl) 3 (3 (trifluoromethyl)phenyl) 2h benzo[e][1,3]oxazine 2,4(3h) dione aggrecan benzamide derivative immunoglobulin enhancer binding protein inducible nitric oxide synthase interferon regulatory factor 1 matrix metalloproteinase proteoglycan quercetin STAT3 protein transcription factor AP 1 tumor necrosis factor unclassified drug collagen collagenase 3 nitric oxide protective agent quercetin transcription factor tumor necrosis factor animal cell animal model animal tissue antiinflammatory activity arthritis Article chondrocyte comparative molecular similarity indices analysis controlled study enzyme activity gel mobility shift assay human human cell IC50 immunohistochemistry immunomodulation MTT assay nonhuman pig protein degradation protein expression rat reverse transcription polymerase chain reaction signal transduction Western blotting animal arthritis chemistry drug effect metabolism pathology structure activity relation Animals Arthritis Chondrocytes Collagen Immunomodulation Matrix Metalloproteinase 13 Nitric Oxide Nitric Oxide Synthase Type II Protective Agents Proteoglycans Quercetin Structure-Activity Relationship Swine Transcription Factors Tumor Necrosis Factor-alpha 10.3390/ijms19051453 International Journal of Molecular Sciences 19 5 1453 2020-11-23T08:48:49Z 2020-11-23T08:48:49Z 2018 Article Liu, F.-C, Lu, J.-W, Chien, C.-Y, Huang, H.-S, Lee, C.-C, Lien, S.-B, Lin, L.-C, Chen, L.W, Ho, Y.-J, Shen, M.-C, Ho, L.-J, Lai, J.-H (2018). Arthroprotective effects of Cf-02 sharing structural similarity with quercetin. International Journal of Molecular Sciences 19 (5) : 1453. ScholarBank@NUS Repository. https://doi.org/10.3390/ijms19051453 1661-6596 https://scholarbank.nus.edu.sg/handle/10635/183845 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ MDPI Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	6 (2,4 difluorophenyl) 3 (3 (trifluoromethyl)phenyl) 2h benzo[e][1,3]oxazine 2,4(3h) dione aggrecan benzamide derivative immunoglobulin enhancer binding protein inducible nitric oxide synthase interferon regulatory factor 1 matrix metalloproteinase proteoglycan quercetin STAT3 protein transcription factor AP 1 tumor necrosis factor unclassified drug collagen collagenase 3 nitric oxide protective agent quercetin transcription factor tumor necrosis factor animal cell animal model animal tissue antiinflammatory activity arthritis Article chondrocyte comparative molecular similarity indices analysis controlled study enzyme activity gel mobility shift assay human human cell IC50 immunohistochemistry immunomodulation MTT assay nonhuman pig protein degradation protein expression rat reverse transcription polymerase chain reaction signal transduction Western blotting animal arthritis chemistry drug effect metabolism pathology structure activity relation Animals Arthritis Chondrocytes Collagen Immunomodulation Matrix Metalloproteinase 13 Nitric Oxide Nitric Oxide Synthase Type II Protective Agents Proteoglycans Quercetin Structure-Activity Relationship Swine Transcription Factors Tumor Necrosis Factor-alpha
spellingShingle	6 (2,4 difluorophenyl) 3 (3 (trifluoromethyl)phenyl) 2h benzo[e][1,3]oxazine 2,4(3h) dione aggrecan benzamide derivative immunoglobulin enhancer binding protein inducible nitric oxide synthase interferon regulatory factor 1 matrix metalloproteinase proteoglycan quercetin STAT3 protein transcription factor AP 1 tumor necrosis factor unclassified drug collagen collagenase 3 nitric oxide protective agent quercetin transcription factor tumor necrosis factor animal cell animal model animal tissue antiinflammatory activity arthritis Article chondrocyte comparative molecular similarity indices analysis controlled study enzyme activity gel mobility shift assay human human cell IC50 immunohistochemistry immunomodulation MTT assay nonhuman pig protein degradation protein expression rat reverse transcription polymerase chain reaction signal transduction Western blotting animal arthritis chemistry drug effect metabolism pathology structure activity relation Animals Arthritis Chondrocytes Collagen Immunomodulation Matrix Metalloproteinase 13 Nitric Oxide Nitric Oxide Synthase Type II Protective Agents Proteoglycans Quercetin Structure-Activity Relationship Swine Transcription Factors Tumor Necrosis Factor-alpha Liu, F.-C Lu, J.-W Chien, C.-Y Huang, H.-S Lee, C.-C Lien, S.-B Lin, L.-C Chen, L.W Ho, Y.-J Shen, M.-C Ho, L.-J Lai, J.-H Arthroprotective effects of Cf-02 sharing structural similarity with quercetin
description	10.3390/ijms19051453
author2	BIOLOGICAL SCIENCES
author_facet	BIOLOGICAL SCIENCES Liu, F.-C Lu, J.-W Chien, C.-Y Huang, H.-S Lee, C.-C Lien, S.-B Lin, L.-C Chen, L.W Ho, Y.-J Shen, M.-C Ho, L.-J Lai, J.-H
format	Article
author	Liu, F.-C Lu, J.-W Chien, C.-Y Huang, H.-S Lee, C.-C Lien, S.-B Lin, L.-C Chen, L.W Ho, Y.-J Shen, M.-C Ho, L.-J Lai, J.-H
author_sort	Liu, F.-C
title	Arthroprotective effects of Cf-02 sharing structural similarity with quercetin
title_short	Arthroprotective effects of Cf-02 sharing structural similarity with quercetin
title_full	Arthroprotective effects of Cf-02 sharing structural similarity with quercetin
title_fullStr	Arthroprotective effects of Cf-02 sharing structural similarity with quercetin
title_full_unstemmed	Arthroprotective effects of Cf-02 sharing structural similarity with quercetin
title_sort	arthroprotective effects of cf-02 sharing structural similarity with quercetin
publisher	MDPI
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/183845
_version_	1795374612623654912

Arthroprotective effects of Cf-02 sharing structural similarity with quercetin

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