Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor

• Main Authors: Lau, A.J, Yang, G, Rajaraman, G, Baucom, C.C, Chang, T.K.H
• Other Authors: PHARMACY
• Format: Article
• Published: American Society for Pharmacology and Experimental Therapeutics 2020
• Subjects: constitutive androstane receptor; cytochrome P450 3A4; meclozine; pregnane X receptor; rifampicin; steroid receptor coactivator 1; animal experiment; article; assay; cell based reporter gene assay; cell strain HepG2; controlled study; drug antagonism; drug effect; drug receptor binding; fluorescence resonance energy transfer; gene expression; genetic transfection; human; human cell; ligand binding; liver cell; nonhuman; nucleotide sequence; priority journal; rat; Cells, Cultured; Dose-Response Relationship, Drug; Hep G2 Cells; Hepatocytes; Humans; Meclizine; Protein Binding; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/183913
• Institution: National University of Singapore

10.1124/jpet.110.175927