Kill502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo

10.1182/blood-2007-06-098079

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Main Authors: Nishioka, C, Ikezoe, T, Yang, J, Miwa, A, Tasaka, T, Kuwayama, Y, Togitani, K, Koeffler, H.P, Yokoyama, A
Other Authors: DEPT OF MEDICINE
Format: Article
Published: American Society of Hematology 2020
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Online Access:https://scholarbank.nus.edu.sg/handle/10635/183927
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spelling sg-nus-scholar.10635-1839272023-08-30T22:24:45Z Kill502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo Nishioka, C Ikezoe, T Yang, J Miwa, A Tasaka, T Kuwayama, Y Togitani, K Koeffler, H.P Yokoyama, A DEPT OF MEDICINE antineoplastic agent CD135 antigen imatinib ki 11502 mitogen activated protein kinase protein bcl 2 protein kinase B protein tyrosine kinase inhibitor STAT5 protein unclassified drug antineoplastic agent Ki11502 protein kinase inhibitor protein tyrosine kinase quinoline derivative acute granulocytic leukemia adult aged animal experiment animal model antineoplastic activity apoptosis article cancer inhibition cell cycle arrest cell proliferation cell selection cellular distribution controlled study down regulation drug mechanism female gene mutation human human tissue leukemia leukemia cell male mouse nonhuman priority journal signal transduction animal apoptosis cell proliferation drug antagonism drug effect mouse mutant pathology treatment outcome tumor cell line xenograft Animals Antineoplastic Agents Apoptosis Cell Line, Tumor Cell Proliferation Humans Leukemia Mice Mice, SCID Protein Kinase Inhibitors Quinolines Receptor Protein-Tyrosine Kinases Transplantation, Heterologous Treatment Outcome 10.1182/blood-2007-06-098079 Blood 111 10 5086-5092 2020-11-23T09:02:56Z 2020-11-23T09:02:56Z 2008 Article Nishioka, C, Ikezoe, T, Yang, J, Miwa, A, Tasaka, T, Kuwayama, Y, Togitani, K, Koeffler, H.P, Yokoyama, A (2008). Kill502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo. Blood 111 (10) : 5086-5092. ScholarBank@NUS Repository. https://doi.org/10.1182/blood-2007-06-098079 0006-4971 https://scholarbank.nus.edu.sg/handle/10635/183927 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ American Society of Hematology Unpaywall 20201031
institution National University of Singapore
building NUS Library
continent Asia
country Singapore
Singapore
content_provider NUS Library
collection ScholarBank@NUS
topic antineoplastic agent
CD135 antigen
imatinib
ki 11502
mitogen activated protein kinase
protein bcl 2
protein kinase B
protein tyrosine kinase inhibitor
STAT5 protein
unclassified drug
antineoplastic agent
Ki11502
protein kinase inhibitor
protein tyrosine kinase
quinoline derivative
acute granulocytic leukemia
adult
aged
animal experiment
animal model
antineoplastic activity
apoptosis
article
cancer inhibition
cell cycle arrest
cell proliferation
cell selection
cellular distribution
controlled study
down regulation
drug mechanism
female
gene mutation
human
human tissue
leukemia
leukemia cell
male
mouse
nonhuman
priority journal
signal transduction
animal
apoptosis
cell proliferation
drug antagonism
drug effect
mouse mutant
pathology
treatment outcome
tumor cell line
xenograft
Animals
Antineoplastic Agents
Apoptosis
Cell Line, Tumor
Cell Proliferation
Humans
Leukemia
Mice
Mice, SCID
Protein Kinase Inhibitors
Quinolines
Receptor Protein-Tyrosine Kinases
Transplantation, Heterologous
Treatment Outcome
spellingShingle antineoplastic agent
CD135 antigen
imatinib
ki 11502
mitogen activated protein kinase
protein bcl 2
protein kinase B
protein tyrosine kinase inhibitor
STAT5 protein
unclassified drug
antineoplastic agent
Ki11502
protein kinase inhibitor
protein tyrosine kinase
quinoline derivative
acute granulocytic leukemia
adult
aged
animal experiment
animal model
antineoplastic activity
apoptosis
article
cancer inhibition
cell cycle arrest
cell proliferation
cell selection
cellular distribution
controlled study
down regulation
drug mechanism
female
gene mutation
human
human tissue
leukemia
leukemia cell
male
mouse
nonhuman
priority journal
signal transduction
animal
apoptosis
cell proliferation
drug antagonism
drug effect
mouse mutant
pathology
treatment outcome
tumor cell line
xenograft
Animals
Antineoplastic Agents
Apoptosis
Cell Line, Tumor
Cell Proliferation
Humans
Leukemia
Mice
Mice, SCID
Protein Kinase Inhibitors
Quinolines
Receptor Protein-Tyrosine Kinases
Transplantation, Heterologous
Treatment Outcome
Nishioka, C
Ikezoe, T
Yang, J
Miwa, A
Tasaka, T
Kuwayama, Y
Togitani, K
Koeffler, H.P
Yokoyama, A
Kill502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo
description 10.1182/blood-2007-06-098079
author2 DEPT OF MEDICINE
author_facet DEPT OF MEDICINE
Nishioka, C
Ikezoe, T
Yang, J
Miwa, A
Tasaka, T
Kuwayama, Y
Togitani, K
Koeffler, H.P
Yokoyama, A
format Article
author Nishioka, C
Ikezoe, T
Yang, J
Miwa, A
Tasaka, T
Kuwayama, Y
Togitani, K
Koeffler, H.P
Yokoyama, A
author_sort Nishioka, C
title Kill502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo
title_short Kill502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo
title_full Kill502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo
title_fullStr Kill502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo
title_full_unstemmed Kill502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo
title_sort kill502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo
publisher American Society of Hematology
publishDate 2020
url https://scholarbank.nus.edu.sg/handle/10635/183927
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