Targeting akt/mtor in oral cancer: Mechanisms and advances in clinical trials

Targeting akt/mtor in oral cancer: Mechanisms and advances in clinical trials

10.3390/ijms21093285

Saved in:

Bibliographic Details
Main Authors:	Harsha, C., Banik, K., Ang, H.L., Girisa, S., Vikkurthi, R., Parama, D., Rana, V., Shabnam, B., Khatoon, E., Kumar, A.P., Kunnumakkara, A.B.
Other Authors:	DEPT OF PHARMACOLOGY
Format:	Article
Published:	MDPI AG 2021
Subjects:	Akt Inhibitors MTOR Oral cancer Pathway Treatment
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/198077
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	National University of Singapore

Similar Items

TIPE2 induced the proliferation, survival, and migration of lung cancer cells through modulation of AKt/mTOR/NF-κB signaling cascade
by: Bordoloi, D., et al.
Published: (2021)

PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
by: Glaviano, A, et al.
Published: (2023)

Casticin-induced inhibition of cell growth and survival are mediated through the dual modulation of Akt/mTOR signaling cascade
by: Lee, J.H., et al.
Published: (2022)

NGAL is downregulated in oral squamous cell carcinoma and leads to increased survival, proliferation, migration and chemoresistance
by: Monisha J., et al.
Published: (2019)

γ-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model
by: Siveen, K.S., et al.
Published: (2014)

An in vitro assay for the kinase activity of mTOR complex 2
by: Huang, J.
Published: (2016)

Brassinin represses invasive potential of lung carcinoma cells through deactivation of PI3K/Akt/mTOR signaling cascade
by: Yang, M.H., et al.
Published: (2021)

Isoform-specific role of akt in oral squamous cell carcinoma
by: Roy, N.K., et al.
Published: (2021)

Increased Akt-Driven Glycolysis Is the Basis for the Higher Potency of CD137L-DCs
by: Zeng, Q, et al.
Published: (2019)

Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy
by: Wu, Y.-T., et al.
Published: (2011)

28S rRNA is inducibly pseudouridylated by the mTOR pathway translational control in CHO cell cultures
by: Courtes, F.C., et al.
Published: (2014)

Molecular mechanisms of tumor resistance to PI3K-mTOR-targeted therapy
by: Tan, J., et al.
Published: (2014)

ABT-869, a multi-targeted tyrosine kinase inhibitor, in combination with rapamycin is effective for subcutaneous hepatocellular carcinoma xenograft
by: Jasinghe, V.J., et al.
Published: (2011)

Redox control of cytosolic Akt phosphorylation in PTEN null cells
by: Luo, L., et al.
Published: (2014)

Myostatin regulates cardiomyocyte growth through modulation of Akt signaling
by: Morissette M.R., et al.
Published: (2018)

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways
by: Kannaiyan, R., et al.
Published: (2014)

Impaired autophagy due to constitutive mTOR activation sensitizes TSC2-null cells to cell death under stress
by: Ng, S., et al.
Published: (2014)

mTOR as a potential therapeutic target for treatment of keloids and excessive scars
by: Ong, C.T., et al.
Published: (2011)

EFFECTS OF INHIBITING THE MAMMALIAN TARGET OF RAPAMYCIN (MTOR) PATHWAY AND TELOMERASE IN BREAST CANCER CELLS
by: GOPALAKRISHNAN KALPANA
Published: (2011)

Potential of zerumbone as an anti-cancer agent
by: Girisa, S., et al.
Published: (2021)

An investigation on the therapeutic potential of butein, a tretrahydroxychalcone against human oral squamous cell carcinoma
by: Bordoloi, D., et al.
Published: (2022)

Phosphorylation of the survival kinase Akt by superoxide is dependent on an ascorbate-reversible oxidation of PTEN
by: Lim, S., et al.
Published: (2011)

Redox Regulation of Akt Phosphorylation in PTEN-/- Mouse Embryonic Fibroblasts
by: LUO LE
Published: (2011)

Translatomics Study of Chinese Hamster Ovary Cell Cultures
by: COURTES FRANCK CEDRIC
Published: (2013)

IDENTIFICATION OF PREDICTIVE BIOMARKERS FOR CHEMOTHERAPY RESISTANCE AND UNDERSTANDING MECHANISMS OF ANTI-TUMORAL EFFECTS OF SIMVASTATIN IN BREAST CANCER
by: WANG TINGTING
Published: (2015)

A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase
by: Zhou, J, et al.
Published: (2020)

Computational Modeling of Cell Signaling Dynamics: Hypothesis Management and Parameter Estimation Methods Applied to the Akt Pathway
by: NIM TRI HIEU
Published: (2013)

ACTIVATION OF PI3K/AKT PATHWAY BY DP103-P110α INTERACTION PROMOTES TUMORIGENIC CAPACITY OF GASTRIC CANCER CELLS
by: SHIKHA SATENDRA SINGH
Published: (2017)

Luteolin induces G1 arrest in human nasopharyngeal carcinoma cells via the Akt-GSK-3β-Cyclin D1 pathway
by: Ong, C.-S., et al.
Published: (2014)

Gene expression profiling in R-flurbiprofen-treated prostate cancer: R-Flurbiprofen regulates prostate stem cell antigen through activation of AKT kinase
by: Zemskova, M., et al.
Published: (2011)

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma
by: Moore, N.F, et al.
Published: (2020)

A study to decipher the mechanism involved in the oxidation of the phosphatase PTEN by reactive oxygen species and its relevance to the activation of the survival kinase AKT by growth factors.
by: LIM SHARON
Published: (2010)

Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways
by: Hu, Y., et al.
Published: (2011)

The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β-catenin signaling
by: Tao, C., et al.
Published: (2021)

PI3K/AKT Signaling Tips the Balance of Cytoskeletal Forces for Cancer Progression
by: Deng, Shuo, et al.
Published: (2023)

Assessing the Relationship Between Nitrate-Reducing Capacity of the Oral Microbiome and Systemic Outcomes
by: Goh, CE, et al.
Published: (2022)

Etlingera elatior Extract promotes cell death in B16 melanoma cells via down-regulation of ERK and Akt signaling pathways.
by: Aungkana Krajarng, et al.
Published: (2019)

Redox stress regulates cell proliferation and apoptosis of human hepatoma through Akt protein phosphorylation
by: Shi, D.-Y., et al.
Published: (2014)

Mechanisms of resistance to pi3k inhibitors in cancer: Adaptive responses, drug tolerance and cellular plasticity
by: Wright, Sarah Christine Elisabeth, et al.
Published: (2022)

Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway
by: Tan, S.-H., et al.
Published: (2014)