PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

• Main Authors: Glaviano, A, Foo, ASC, Lam, HY, Yap, KCH, Jacot, W, Jones, RH, Eng, H, Nair, MG, Makvandi, P, Geoerger, B, Kulke, MH, Baird, RD, Prabhu, JS, Carbone, D, Pecoraro, C, Teh, DBL, Sethi, G, Cavalieri, V, Lin, KH, Javidi-Sharifi, NR, Toska, E, Davids, MS, Brown, JR, Diana, P, Stebbing, J, Fruman, DA, Kumar, AP
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Review
• Published: Springer Science and Business Media LLC 2023
• Subjects: AKT inhibitors; ATP-competitive mTOR inhibitors; Allosteric mTOR inhibitors; Bi-steric mTOR inhibitors; Cancer; Dual PI3K/mTOR inhibitors; Isoform-specific PI3K inhibitors; PDK1 inhibitors; PI3K/AKT/mTORC pathway; Pan PI3K inhibitors; Humans; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases; Neoplasms
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/245930
• Institution: National University of Singapore

10.1186/s12943-023-01827-6