Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

• Main Authors: Ling, S.-C., Dastidar, S.G., Tokunaga, S., Ho, W.Y., Lim, K., Ilieva, H., Parone, P.A., Tyan, S.-H., Tse, T.M., Chang, J.-C., Platoshyn, O., Bui, N.B., Bui, A., Vetto, A., Sun, S., McAlonis-Downes, M., Han, J.S., Swing, D., Kapeli, K., Yeo, G.W., Tessarollo, L., Marsala, M., Shaw, C.E., Tucker-Kellogg, G., La Spada, A.R., Lagier-Tourenne, C., Da Cruz, S., Cleveland, D.W.
• Other Authors: PHYSIOLOGY
• Format: Article
• Published: NLM (Medline) 2021
• Subjects: amyotrophic lateral sclerosis (ALS); autophagy-lysosome; frontotemporal degeneration (FTD); FUS; homeostasis; mouse; neuroscience; RNA metabolism
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/209999
• Institution: National University of Singapore

10.7554/eLife.40811