Liver fibrosis and CD206⁺ macrophage accumulation are suppressed by anti-GM-CSF therapy

• Main Authors: Tan-Garcia, A, Lai, F, Sheng Yeong, JP, Irac, SE, Ng, PY, Msallam, R, Tatt Lim, JC, Wai, LE, Tham, CYL, Choo, SP, Lim, T, Young, DY, D'Ambrosio, R, Degasperi, E, Perbellini, R, Newell, E, Le Bert, N, Ginhoux, F, Bertoletti, A, Chen, Q, Dutertre, CA
• Other Authors: DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
• Format: Article
• Published: Elsevier BV 2022
• Subjects: ALT, alanine aminotransferase; BAMBI, BMP and Activin Membrane-bound Inhibitor; CD206+ macrophages; DAA, direct-acting antiviral; DC, dendritic cell; FFPE, formalin-fixed paraffin-embedded; GM-CSF; GM-CSF, granulocyte-macrophage colony-stimulating factor; HCC, hepatocellular carcinoma; HCV; HIER, heat-induced epitope retrieval; HSC, hepatic stellate cells; ICS, intracellular cytokine staining; Intrahepatic macrophages; LPS, lipopolysaccharide; LSM, liver stiffness measurement; MS, multiple sclerosis; NASH; NASH, non-alcoholic steatohepatitis; PBMCs, peripheral blood mononuclear cells; RA, rheumatoid arthritis; SVR, sustained virological response; TCR, T cell receptor; TMA, tissue microarray; TNFα, tumour necrosis factor-α; TSA, tyramide signal amplification; anti-GM-CSF neutralizing antibody; fibrosis; moMΦs, monocyte-derived macrophage-like cells; t-SNE, t-distributed stochastic neighbour embedding
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/212796
• Institution: National University of Singapore

10.1016/j.jhepr.2019.11.006