JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality

10.1126/sciadv.abe4724

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Main Authors:	Stebbing, Justin, Nievas, Gines Sanchez, Falcone, Marco, Youhanna, Sonia, Richardson, Peter, Ottaviani, Silvia, Shen, Joanne X, Sommerauer, Christian, Tiseo, Giusy, Ghiadoni, Lorenzo, Virdis, Agostino, Monzani, Fabio, Rizos, Luis Romero, Forfori, Francesco, Avendano-Cespedes, Almudena, De Marco, Salvatore, Carrozzi, Laura, Lena, Fabio, Sanchez-Jurado, Pedro Manuel, Lacerenza, Leonardo Gianluca, Cesira, Nencioni, Caldevilla-Bernardo, David, Perrella, Antonio, Niccoli, Laura, Mendez, Lourdes Saez, Matarrese, Daniela, Goletti, Delia, Tan, Yee-Joo, Monteil, Vanessa, Dranitsaris, George, Cantini, Fabrizio, Farcomeni, Alessio, Dutta, Shuchismita, Burley, Stephen K, Zhang, Haibo, Pistello, Mauro, Li, William, Romero, Marta Mas, Pretel, Fernando Andres, Simon-Talero, Rafaela Sanchez, Garcia-Molina, Rafael, Kutter, Claudia, Felce, James H, Nizami, Zehra F, Miklosi, Andras G, Penninger, Josef M, Menichetti, Francesco, Mirazimi, Ali, Abizanda, Pedro, Lauschke, Volker M
Other Authors:	MICROBIOLOGY AND IMMUNOLOGY
Format:	Article
Language:	English
Published:	AMER ASSOC ADVANCEMENT SCIENCE 2022
Subjects:	Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics RHEUMATOID-ARTHRITIS FUNCTIONAL RECEPTOR BARICITINIB PLACEBO PROTEIN INJURY
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/219373
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Institution:	National University of Singapore
Language:	English

id	sg-nus-scholar.10635-219373
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spelling	sg-nus-scholar.10635-2193732024-03-27T08:07:07Z JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality Stebbing, Justin Nievas, Gines Sanchez Falcone, Marco Youhanna, Sonia Richardson, Peter Ottaviani, Silvia Shen, Joanne X Sommerauer, Christian Tiseo, Giusy Ghiadoni, Lorenzo Virdis, Agostino Monzani, Fabio Rizos, Luis Romero Forfori, Francesco Avendano-Cespedes, Almudena De Marco, Salvatore Carrozzi, Laura Lena, Fabio Sanchez-Jurado, Pedro Manuel Lacerenza, Leonardo Gianluca Cesira, Nencioni Caldevilla-Bernardo, David Perrella, Antonio Niccoli, Laura Mendez, Lourdes Saez Matarrese, Daniela Goletti, Delia Tan, Yee-Joo Monteil, Vanessa Dranitsaris, George Cantini, Fabrizio Farcomeni, Alessio Dutta, Shuchismita Burley, Stephen K Zhang, Haibo Pistello, Mauro Li, William Romero, Marta Mas Pretel, Fernando Andres Simon-Talero, Rafaela Sanchez Garcia-Molina, Rafael Kutter, Claudia Felce, James H Nizami, Zehra F Miklosi, Andras G Penninger, Josef M Menichetti, Francesco Mirazimi, Ali Abizanda, Pedro Lauschke, Volker M MICROBIOLOGY AND IMMUNOLOGY Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics RHEUMATOID-ARTHRITIS FUNCTIONAL RECEPTOR BARICITINIB PLACEBO PROTEIN INJURY 10.1126/sciadv.abe4724 SCIENCE ADVANCES 7 1 2022-04-20T06:43:41Z 2022-04-20T06:43:41Z 2021-01-01 2022-04-20T04:31:19Z Article Stebbing, Justin, Nievas, Gines Sanchez, Falcone, Marco, Youhanna, Sonia, Richardson, Peter, Ottaviani, Silvia, Shen, Joanne X, Sommerauer, Christian, Tiseo, Giusy, Ghiadoni, Lorenzo, Virdis, Agostino, Monzani, Fabio, Rizos, Luis Romero, Forfori, Francesco, Avendano-Cespedes, Almudena, De Marco, Salvatore, Carrozzi, Laura, Lena, Fabio, Sanchez-Jurado, Pedro Manuel, Lacerenza, Leonardo Gianluca, Cesira, Nencioni, Caldevilla-Bernardo, David, Perrella, Antonio, Niccoli, Laura, Mendez, Lourdes Saez, Matarrese, Daniela, Goletti, Delia, Tan, Yee-Joo, Monteil, Vanessa, Dranitsaris, George, Cantini, Fabrizio, Farcomeni, Alessio, Dutta, Shuchismita, Burley, Stephen K, Zhang, Haibo, Pistello, Mauro, Li, William, Romero, Marta Mas, Pretel, Fernando Andres, Simon-Talero, Rafaela Sanchez, Garcia-Molina, Rafael, Kutter, Claudia, Felce, James H, Nizami, Zehra F, Miklosi, Andras G, Penninger, Josef M, Menichetti, Francesco, Mirazimi, Ali, Abizanda, Pedro, Lauschke, Volker M (2021-01-01). JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality. SCIENCE ADVANCES 7 (1). ScholarBank@NUS Repository. https://doi.org/10.1126/sciadv.abe4724 23752548 https://scholarbank.nus.edu.sg/handle/10635/219373 en AMER ASSOC ADVANCEMENT SCIENCE Elements
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
language	English
topic	Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics RHEUMATOID-ARTHRITIS FUNCTIONAL RECEPTOR BARICITINIB PLACEBO PROTEIN INJURY
spellingShingle	Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics RHEUMATOID-ARTHRITIS FUNCTIONAL RECEPTOR BARICITINIB PLACEBO PROTEIN INJURY Stebbing, Justin Nievas, Gines Sanchez Falcone, Marco Youhanna, Sonia Richardson, Peter Ottaviani, Silvia Shen, Joanne X Sommerauer, Christian Tiseo, Giusy Ghiadoni, Lorenzo Virdis, Agostino Monzani, Fabio Rizos, Luis Romero Forfori, Francesco Avendano-Cespedes, Almudena De Marco, Salvatore Carrozzi, Laura Lena, Fabio Sanchez-Jurado, Pedro Manuel Lacerenza, Leonardo Gianluca Cesira, Nencioni Caldevilla-Bernardo, David Perrella, Antonio Niccoli, Laura Mendez, Lourdes Saez Matarrese, Daniela Goletti, Delia Tan, Yee-Joo Monteil, Vanessa Dranitsaris, George Cantini, Fabrizio Farcomeni, Alessio Dutta, Shuchismita Burley, Stephen K Zhang, Haibo Pistello, Mauro Li, William Romero, Marta Mas Pretel, Fernando Andres Simon-Talero, Rafaela Sanchez Garcia-Molina, Rafael Kutter, Claudia Felce, James H Nizami, Zehra F Miklosi, Andras G Penninger, Josef M Menichetti, Francesco Mirazimi, Ali Abizanda, Pedro Lauschke, Volker M JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality
description	10.1126/sciadv.abe4724
author2	MICROBIOLOGY AND IMMUNOLOGY
author_facet	MICROBIOLOGY AND IMMUNOLOGY Stebbing, Justin Nievas, Gines Sanchez Falcone, Marco Youhanna, Sonia Richardson, Peter Ottaviani, Silvia Shen, Joanne X Sommerauer, Christian Tiseo, Giusy Ghiadoni, Lorenzo Virdis, Agostino Monzani, Fabio Rizos, Luis Romero Forfori, Francesco Avendano-Cespedes, Almudena De Marco, Salvatore Carrozzi, Laura Lena, Fabio Sanchez-Jurado, Pedro Manuel Lacerenza, Leonardo Gianluca Cesira, Nencioni Caldevilla-Bernardo, David Perrella, Antonio Niccoli, Laura Mendez, Lourdes Saez Matarrese, Daniela Goletti, Delia Tan, Yee-Joo Monteil, Vanessa Dranitsaris, George Cantini, Fabrizio Farcomeni, Alessio Dutta, Shuchismita Burley, Stephen K Zhang, Haibo Pistello, Mauro Li, William Romero, Marta Mas Pretel, Fernando Andres Simon-Talero, Rafaela Sanchez Garcia-Molina, Rafael Kutter, Claudia Felce, James H Nizami, Zehra F Miklosi, Andras G Penninger, Josef M Menichetti, Francesco Mirazimi, Ali Abizanda, Pedro Lauschke, Volker M
format	Article
author	Stebbing, Justin Nievas, Gines Sanchez Falcone, Marco Youhanna, Sonia Richardson, Peter Ottaviani, Silvia Shen, Joanne X Sommerauer, Christian Tiseo, Giusy Ghiadoni, Lorenzo Virdis, Agostino Monzani, Fabio Rizos, Luis Romero Forfori, Francesco Avendano-Cespedes, Almudena De Marco, Salvatore Carrozzi, Laura Lena, Fabio Sanchez-Jurado, Pedro Manuel Lacerenza, Leonardo Gianluca Cesira, Nencioni Caldevilla-Bernardo, David Perrella, Antonio Niccoli, Laura Mendez, Lourdes Saez Matarrese, Daniela Goletti, Delia Tan, Yee-Joo Monteil, Vanessa Dranitsaris, George Cantini, Fabrizio Farcomeni, Alessio Dutta, Shuchismita Burley, Stephen K Zhang, Haibo Pistello, Mauro Li, William Romero, Marta Mas Pretel, Fernando Andres Simon-Talero, Rafaela Sanchez Garcia-Molina, Rafael Kutter, Claudia Felce, James H Nizami, Zehra F Miklosi, Andras G Penninger, Josef M Menichetti, Francesco Mirazimi, Ali Abizanda, Pedro Lauschke, Volker M
author_sort	Stebbing, Justin
title	JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality
title_short	JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality
title_full	JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality
title_fullStr	JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality
title_full_unstemmed	JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality
title_sort	jak inhibition reduces sars-cov-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality
publisher	AMER ASSOC ADVANCEMENT SCIENCE
publishDate	2022
url	https://scholarbank.nus.edu.sg/handle/10635/219373
_version_	1795301761331757056

JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality

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