Symmetric activation and modulation of the human calcium-sensing receptor

• Main Authors: Park, J, Zuo, H, Frangaj, A, Fu, Z, Yen, LY, Zhang, Z, Mosyak, L, Slavkovich, VN, Liu, J, Ray, KM, Cao, B, Vallese, F, Geng, Y, Chen, S, Grassucci, R, Dandey, VP, Tan, YZ, Eng, E, Lee, Y, Kloss, B, Liu, Z, Hendrickson, WA, Potter, CS, Carragher, B, Graziano, J, Conigrave, AD, Frank, J, Clarke, OB, Fan, QR
• Other Authors: BIOLOGICAL SCIENCES
• Format: Article
• Published: Proceedings of the National Academy of Sciences 2022
• Subjects: activation mechanism; allosteric modulation; calcium-sensing receptor; cryo-EM structure; symmetry; Calcium; Cryoelectron Microscopy; Gene Expression Regulation; HEK293 Cells; Homeostasis; Humans; Models, Molecular; Protein Conformation; Protein Domains; Receptors, Calcium-Sensing; Signal Transduction
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/227196
• Institution: National University of Singapore

10.1073/pnas.2115849118