A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion

A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion

10.1186/s13059-021-02397-w

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Bibliographic Details
Main Authors: Witte, Franziska, Ruiz-Orera, Jorge, Mattioli, Camilla Ciolli, Blachut, Susanne, Adami, Eleonora, Schulz, Jana Felicitas, Schneider-Lunitz, Valentin, Hummel, Oliver, Patone, Giannino, Mücke, Michael Benedikt, Šilhavý, Jan, Heinig, Matthias, Bottolo, Leonardo, Sanchis, Daniel, Vingron, Martin, Chekulaeva, Marina, Pravenec, Michal, Hubner, Norbert, van Heesch, Sebastiaan
Other Authors: DUKE-NUS MEDICAL SCHOOL
Format: Article
Published: BioMed Central Ltd 2022
Subjects:
Cardiac hypertrophy
Complex disease
Genetic variation
HXB/BXH rat recombinant inbred panel
Ribosome biogenesis
Ribosome profiling
Ribosomopathy
Spontaneously hypertensive rats (SHR)
trans QTL mapping
Translational efficiency
Online Access:https://scholarbank.nus.edu.sg/handle/10635/231930
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Institution: National University of Singapore

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https://scholarbank.nus.edu.sg/handle/10635/231930

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