A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion

• Main Authors: Witte, Franziska, Ruiz-Orera, Jorge, Mattioli, Camilla Ciolli, Blachut, Susanne, Adami, Eleonora, Schulz, Jana Felicitas, Schneider-Lunitz, Valentin, Hummel, Oliver, Patone, Giannino, Mücke, Michael Benedikt, Šilhavý, Jan, Heinig, Matthias, Bottolo, Leonardo, Sanchis, Daniel, Vingron, Martin, Chekulaeva, Marina, Pravenec, Michal, Hubner, Norbert, van Heesch, Sebastiaan
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: BioMed Central Ltd 2022
• Subjects: Cardiac hypertrophy; Complex disease; Genetic variation; HXB/BXH rat recombinant inbred panel; Ribosome biogenesis; Ribosome profiling; Ribosomopathy; Spontaneously hypertensive rats (SHR); trans QTL mapping; Translational efficiency
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/231930
• Institution: National University of Singapore

10.1186/s13059-021-02397-w