Targeted integration of EpCAM-specific CAR in human induced pluripotent stem cells and their differentiation into NK cells

Targeted integration of EpCAM-specific CAR in human induced pluripotent stem cells and their differentiation into NK cells

10.1186/s13287-021-02648-4

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Bibliographic Details
Main Authors: Tang, Shin Yi, Zha, Shijun, Du, Zhicheng, Zeng, Jieming, Zhu, Detu, Luo, Yumei, Wang, Shu
Other Authors: BIOLOGICAL SCIENCES
Format: Article
Published: BioMed Central Ltd 2022
Subjects:
Adeno-associated virus integration site 1 (AAVS1)
Chimeric antigen receptors (CAR)
Epithelial cell adhesion molecule (EpCAM)
Genetic engineering
Immunotherapy
Induced pluripotent stem cells (iPSC)
Natural killer cells (NK)
NK differentiation
Targeted integration
Zinc finger nuclease (ZFN)
Online Access:https://scholarbank.nus.edu.sg/handle/10635/233532
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Institution: National University of Singapore

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https://scholarbank.nus.edu.sg/handle/10635/233532

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