Synthetic combinations of missense polymorphic genetic changes underlying Down syndrome susceptibility

• Main Authors: Jackson, Rebecca A, Nguyen, Mai Linh, Barrett, Angela N, Tan, Yuan Yee, Choolani, Mahesh A, Chen, Ee Sin
• Other Authors: BIOCHEMISTRY
• Format: Review
• Language: English
• Published: SPRINGER BASEL AG 2023
• Subjects: Science & Technology; Life Sciences & Biomedicine; Biochemistry & Molecular Biology; Cell Biology; Trisomy 21; Missense; MTHFR; p53; One-carbon metabolism; Folate; Polymorphism; SNP; MATERNAL RISK-FACTORS; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; REDUCED FOLATE CARRIER; FOLIC-ACID SUPPLEMENTATION; METHIONINE SYNTHASE REDUCTASE; CYSTATHIONINE BETA-SYNTHASE; TUMOR-SUPPRESSOR GENE; NEURAL-TUBE DEFECTS; HUMAN-CHROMOSOME 21; HOMOCYSTEINE METABOLISM
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/239191
• Institution: National University of Singapore

10.1007/s00018-016-2276-0