Evaluation of Protein Backbone Alphabets: Using Predicted Local Structure for Fold Recognition

• Main Author: SHIM, Kyong Jin
• Format: text
• Language: English
• Published: Institutional Knowledge at Singapore Management University 2010
• Subjects: Databases and Information Systems
• Online Access: https://ink.library.smu.edu.sg/sis_research/1527; https://ink.library.smu.edu.sg/context/sis_research/article/2526/viewcontent/10_015.pdf
• Institution: Singapore Management University

Optimally combining available information is one of the key challenges in knowledge-driven prediction techniques. In this study, we evaluate six Phi and Psi-based backbone alphabets. We show that the addition of predicted backbone conformations to SVM classifiers can improve fold recognition. Our ex...