Chemoprevention Studies of the Flavonoids Quercetin and Rutin in Normal and Azoxymethane Treated Mouse Colon

• Main Authors: YANG, K., Lamprecht, S. A., Liu, Y., Shinozaki, H., Fan, K. H., Leung, Denis H. Y., Newmark, H., Steele, V. E., Kelloff, G. J., Lipkin, M.
• Format: text
• Language: English
• Published: Institutional Knowledge at Singapore Management University 2000
• Subjects: Econometrics; Medicine and Health Sciences
• Online Access: https://ink.library.smu.edu.sg/soe_research/145
• Institution: Singapore Management University

In this study we investigated the chemopreventive effects of quercetin and rutin when added to standard AIN-76A diet and fed to normal and azoxymethane (AOM)-treated mice. Early changes in colonic mucosa were analyzed, including colonic cell proliferation, apoptotic cell death, cyclin D1 expression...