A Modified Dunnett and Tamhane Step-up Approach for Establishing Superiority/Equivalence of a New Treatment Compared with K Standard Treatments
There are still some open questions whether the existing step-up procedures for establishing superiority and equivalence of a new treatment compared with several standard treatments can strongly control the type I familywise error rate (FWE) at the designated level. In this paper we modify one of th...
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| Format: | text |
| Language: | English |
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Institutional Knowledge at Singapore Management University
2001
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| Online Access: | https://ink.library.smu.edu.sg/soe_research/317 |
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| Institution: | Singapore Management University |
| Language: | English |
| Summary: | There are still some open questions whether the existing step-up procedures for establishing superiority and equivalence of a new treatment compared with several standard treatments can strongly control the type I familywise error rate (FWE) at the designated level. In this paper we modify one of the three step-up procedures suggested by Dunnett and Tamhane (16 (1997) Statist. Med. 2489-2506) and then prove that the modified procedure strongly controls the FWE. The method for evaluating the critical values of the modified procedure is also discussed. A simulation study reveals that the modified procedure is generally more powerful than the original procedure. |
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