A Modified Dunnett and Tamhane Step-up Approach for Establishing Superiority/Equivalence of a New Treatment Compared with K Standard Treatments

• Main Author: KWONG, Koon Shing
• Format: text
• Language: English
• Published: Institutional Knowledge at Singapore Management University 2001
• Subjects: Economics
• Online Access: https://ink.library.smu.edu.sg/soe_research/317
• Institution: Singapore Management University

There are still some open questions whether the existing step-up procedures for establishing superiority and equivalence of a new treatment compared with several standard treatments can strongly control the type I familywise error rate (FWE) at the designated level. In this paper we modify one of the three step-up procedures suggested by Dunnett and Tamhane (16 (1997) Statist. Med. 2489-2506) and then prove that the modified procedure strongly controls the FWE. The method for evaluating the critical values of the modified procedure is also discussed. A simulation study reveals that the modified procedure is generally more powerful than the original procedure.