An Extension of the Continual Reassessment Method Using Decision Theory

• المؤلفون الرئيسيون: Leung, Denis H. Y., Wang, Y. G.
• التنسيق: text
• اللغة: English
• منشور في: Institutional Knowledge at Singapore Management University 2002
• الموضوعات: Econometrics; Health Economics
• الوصول للمادة أونلاين: https://ink.library.smu.edu.sg/soe_research/414

The primary goal of a phase I trial is to find the maximally tolerated dose (MTD) of a treatment. The MTD is usually defined in terms of a tolerable probability, q*, of toxicity. Our objective is to find the highest dose with toxicity risk that does not exceed q*, a criterion that is often desired i...