An Extension of the Continual Reassessment Method Using Decision Theory

• Main Authors: Leung, Denis H. Y., Wang, Y. G.
• Format: text
• Language: English
• Published: Institutional Knowledge at Singapore Management University 2002
• Subjects: Econometrics; Health Economics
• Online Access: https://ink.library.smu.edu.sg/soe_research/414
• Institution: Singapore Management University

The primary goal of a phase I trial is to find the maximally tolerated dose (MTD) of a treatment. The MTD is usually defined in terms of a tolerable probability, q*, of toxicity. Our objective is to find the highest dose with toxicity risk that does not exceed q*, a criterion that is often desired i...