Bcl6 Gene Rearrangement and Other Cytogenetic Abnormalities in Diffuse Large Cell Lymphoma

• Main Authors: Offit, K., Louie, D. C., Parsa, N.Z., Roy, P., Leung, Denis H. Y., LoCoco, F., Zelenetz, A., Dalla-Favera, R., Chaganti, R.S.
• Format: text
• Language: English
• Published: Institutional Knowledge at Singapore Management University 1995
• Subjects: Hodgkin's lymphoma; cytogenetics; chromosome; prognosis; Econometrics; Medicine and Health Sciences
• Online Access: https://ink.library.smu.edu.sg/soe_research/441; https://doi.org/10.3109/10428199509054757
• Institution: Singapore Management University

Evidence for rearrangement of the BCL6 gene at 3q27 has been documented in 20-30% of diffuse lymphomas with a large cell component (DLLC), and was found to be of prognostic significance at the time of diagnosis. To incorporate these observations into current cytogenetic and clinical prognostic model...