Isotonic designs for phase I trials

• Main Authors: LEUNG, Denis H. Y., WANG, You-Gan
• Format: text
• Language: English
• Published: Institutional Knowledge at Singapore Management University 2002
• Subjects: Continual reassessment method; Dose escalation; Isotonic regression; Maximum tolerated dose; Phase I trials; Up-and-down method; Econometrics; Medicine and Health Sciences
• Online Access: https://ink.library.smu.edu.sg/soe_research/2155; https://ink.library.smu.edu.sg/context/soe_research/article/3155/viewcontent/IsotonicDesignsPhaseITrials_2001.pdf
• Institution: Singapore Management University

The purpose of a phase I trial in cancer is to determine the level (dose) of the treatment under study that has an acceptable level of adverse effects. Although substantial progress has recently been made in this area using parametric approaches, the method that is widely used is based on treating s...