Reversible acetylcholinesterase inhibitory effect of Tabernaemontana divaricata extract on synaptic transmission in rat CA1 hippocampus

Background & objectives: Acetylcholinesterase inhibitors (AChE-Is) are used for the treatment of Alzheimer's disease (AD). These drugs including galanthamine have been shown to modulate synaptic activity in hippocampus and improve memory processes. Although Tabernaemontana divaricata extrac...

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Main Authors: Pratchayasakul W., Pongchaidecha A., Chattipakorn N., Chattipakorn S.C.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-77949744454&partnerID=40&md5=96673ce36a14f2e33d930840bb0ee3b1
http://www.ncbi.nlm.nih.gov/pubmed/20418555
http://cmuir.cmu.ac.th/handle/6653943832/1042
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-10422014-08-29T09:17:39Z Reversible acetylcholinesterase inhibitory effect of Tabernaemontana divaricata extract on synaptic transmission in rat CA1 hippocampus Pratchayasakul W. Pongchaidecha A. Chattipakorn N. Chattipakorn S.C. Background & objectives: Acetylcholinesterase inhibitors (AChE-Is) are used for the treatment of Alzheimer's disease (AD). These drugs including galanthamine have been shown to modulate synaptic activity in hippocampus and improve memory processes. Although Tabernaemontana divaricata extract (TDE) has been used as traditional medicine for various pharmacological effects, its effect in enhancing cholinergic activity provides additional benefit to its known effects. We investigated whether TDE can modulate the synaptic function in hippocampus and compared its effects to those of galanthamine. Methods: Hippocampal slices were prepared from male Wistar rats, functional effects of TDE were characterized by using pharmacological tools and extracellular recordings of field excitatory postsynaptic potentials (fEPSPs). Results: TDE significantly reduced fEPSPs. The fEPSPs reduction was prevented by atropine, but not pancuronium. These TDE effects were similar to those of galanthamine. Interpretation & conclusions: Our findings indicate that TDE can effectively modulate synaptic responses in the hippocampus similar to galanthamine, suggesting that this traditional medicine could be beneficial in ageing with ACh deprivation in the brain. 2014-08-29T09:17:39Z 2014-08-29T09:17:39Z 2010 Article 9715916 20418555 IMIRE http://www.scopus.com/inward/record.url?eid=2-s2.0-77949744454&partnerID=40&md5=96673ce36a14f2e33d930840bb0ee3b1 http://www.ncbi.nlm.nih.gov/pubmed/20418555 http://cmuir.cmu.ac.th/handle/6653943832/1042 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Background & objectives: Acetylcholinesterase inhibitors (AChE-Is) are used for the treatment of Alzheimer's disease (AD). These drugs including galanthamine have been shown to modulate synaptic activity in hippocampus and improve memory processes. Although Tabernaemontana divaricata extract (TDE) has been used as traditional medicine for various pharmacological effects, its effect in enhancing cholinergic activity provides additional benefit to its known effects. We investigated whether TDE can modulate the synaptic function in hippocampus and compared its effects to those of galanthamine. Methods: Hippocampal slices were prepared from male Wistar rats, functional effects of TDE were characterized by using pharmacological tools and extracellular recordings of field excitatory postsynaptic potentials (fEPSPs). Results: TDE significantly reduced fEPSPs. The fEPSPs reduction was prevented by atropine, but not pancuronium. These TDE effects were similar to those of galanthamine. Interpretation & conclusions: Our findings indicate that TDE can effectively modulate synaptic responses in the hippocampus similar to galanthamine, suggesting that this traditional medicine could be beneficial in ageing with ACh deprivation in the brain.
format Article
author Pratchayasakul W.
Pongchaidecha A.
Chattipakorn N.
Chattipakorn S.C.
spellingShingle Pratchayasakul W.
Pongchaidecha A.
Chattipakorn N.
Chattipakorn S.C.
Reversible acetylcholinesterase inhibitory effect of Tabernaemontana divaricata extract on synaptic transmission in rat CA1 hippocampus
author_facet Pratchayasakul W.
Pongchaidecha A.
Chattipakorn N.
Chattipakorn S.C.
author_sort Pratchayasakul W.
title Reversible acetylcholinesterase inhibitory effect of Tabernaemontana divaricata extract on synaptic transmission in rat CA1 hippocampus
title_short Reversible acetylcholinesterase inhibitory effect of Tabernaemontana divaricata extract on synaptic transmission in rat CA1 hippocampus
title_full Reversible acetylcholinesterase inhibitory effect of Tabernaemontana divaricata extract on synaptic transmission in rat CA1 hippocampus
title_fullStr Reversible acetylcholinesterase inhibitory effect of Tabernaemontana divaricata extract on synaptic transmission in rat CA1 hippocampus
title_full_unstemmed Reversible acetylcholinesterase inhibitory effect of Tabernaemontana divaricata extract on synaptic transmission in rat CA1 hippocampus
title_sort reversible acetylcholinesterase inhibitory effect of tabernaemontana divaricata extract on synaptic transmission in rat ca1 hippocampus
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-77949744454&partnerID=40&md5=96673ce36a14f2e33d930840bb0ee3b1
http://www.ncbi.nlm.nih.gov/pubmed/20418555
http://cmuir.cmu.ac.th/handle/6653943832/1042
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