Reversible acetylcholinesterase inhibitory effect of Tabernaemontana divaricata extract on synaptic transmission in rat CA1 hippocampus

• Main Authors: Pratchayasakul W., Pongchaidecha A., Chattipakorn N., Chattipakorn S.C.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-77949744454&partnerID=40&md5=96673ce36a14f2e33d930840bb0ee3b1; http://www.ncbi.nlm.nih.gov/pubmed/20418555; http://cmuir.cmu.ac.th/handle/6653943832/1042
• Institution: Chiang Mai University

Background & objectives: Acetylcholinesterase inhibitors (AChE-Is) are used for the treatment of Alzheimer's disease (AD). These drugs including galanthamine have been shown to modulate synaptic activity in hippocampus and improve memory processes. Although Tabernaemontana divaricata extrac...