T-type calcium channel as a portal of iron uptake into cardiomyocytes of beta-thalassemic mice

• Main Authors: Kumfu S., Chattipakorn S., Srichairatanakool S., Settakorn J., Fucharoen S., Chattipakorn N.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-78651447796&partnerID=40&md5=f6dda2d5a3c1b138f0ce96fecc96cfaa; http://www.ncbi.nlm.nih.gov/pubmed/21059103; http://cmuir.cmu.ac.th/handle/6653943832/1053
• Institution: Chiang Mai University

Objectives: Iron-overload condition can be found in β-thalassemic patients with regular blood transfusion, leading to iron deposition in various organs including the heart. Elevated cardiac iron causes iron-overload cardiomyopathy, a condition that provokes mortality because of heart failure in pati...