TBX22 mutation associated with cleft lip/palate, hypodontia, and limb anomaly
Mutations in TBX22 are known causes of cleft palate with/without ankyloglossia. We identified a hemizygous missense c.452G>T (p.Arg151Leu) mutation in a Thai boy who had unilateral complete cleft lip and palate, agenesis of a maxillary second premolar, ankyloglossia, hypoplastic carpal bones, and...
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2014
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th-cmuir.6653943832-11442014-08-29T09:17:48Z TBX22 mutation associated with cleft lip/palate, hypodontia, and limb anomaly Kaewkhampa A. Jotikasthira D. Malaivijitnond S. Kantaputra P. Mutations in TBX22 are known causes of cleft palate with/without ankyloglossia. We identified a hemizygous missense c.452G>T (p.Arg151Leu) mutation in a Thai boy who had unilateral complete cleft lip and palate, agenesis of a maxillary second premolar, ankyloglossia, hypoplastic carpal bones, and hypoplastic right thumb. Our study has demonstrated that TBX22 mutation is associated not only with cleft palate and ankyloglossia, but also cleft lip and palate and tooth agenesis. Phenotypic variability caused by a single nucleotide substitution is clearly demonstrated. 2014-08-29T09:17:48Z 2014-08-29T09:17:48Z 2012 Article 10556656 10.1597/10-208 CPJOE http://www.scopus.com/inward/record.url?eid=2-s2.0-84858612750&partnerID=40&md5=1661983d125cfafa8b1b2fbe988b7a93 http://cmuir.cmu.ac.th/handle/6653943832/1144 English |
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Mutations in TBX22 are known causes of cleft palate with/without ankyloglossia. We identified a hemizygous missense c.452G>T (p.Arg151Leu) mutation in a Thai boy who had unilateral complete cleft lip and palate, agenesis of a maxillary second premolar, ankyloglossia, hypoplastic carpal bones, and hypoplastic right thumb. Our study has demonstrated that TBX22 mutation is associated not only with cleft palate and ankyloglossia, but also cleft lip and palate and tooth agenesis. Phenotypic variability caused by a single nucleotide substitution is clearly demonstrated. |
| format |
Article |
| author |
Kaewkhampa A. Jotikasthira D. Malaivijitnond S. Kantaputra P. |
| spellingShingle |
Kaewkhampa A. Jotikasthira D. Malaivijitnond S. Kantaputra P. TBX22 mutation associated with cleft lip/palate, hypodontia, and limb anomaly |
| author_facet |
Kaewkhampa A. Jotikasthira D. Malaivijitnond S. Kantaputra P. |
| author_sort |
Kaewkhampa A. |
| title |
TBX22 mutation associated with cleft lip/palate, hypodontia, and limb anomaly |
| title_short |
TBX22 mutation associated with cleft lip/palate, hypodontia, and limb anomaly |
| title_full |
TBX22 mutation associated with cleft lip/palate, hypodontia, and limb anomaly |
| title_fullStr |
TBX22 mutation associated with cleft lip/palate, hypodontia, and limb anomaly |
| title_full_unstemmed |
TBX22 mutation associated with cleft lip/palate, hypodontia, and limb anomaly |
| title_sort |
tbx22 mutation associated with cleft lip/palate, hypodontia, and limb anomaly |
| publishDate |
2014 |
| url |
http://www.scopus.com/inward/record.url?eid=2-s2.0-84858612750&partnerID=40&md5=1661983d125cfafa8b1b2fbe988b7a93 http://cmuir.cmu.ac.th/handle/6653943832/1144 |
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