DPP4-inhibitor improves neuronal insulin receptor function, Brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption

• Main Authors: Pipatpiboon N., Pintana H., Pratchayasakul W., Chattipakorn N., Chattipakorn S.C.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84874525661&partnerID=40&md5=0f2a873cad867fc53e3fc1e6b9335ea4; http://www.ncbi.nlm.nih.gov/pubmed/23240760; http://cmuir.cmu.ac.th/handle/6653943832/1167
• Institution: Chiang Mai University

High-fat diet (HFD) consumption has been demonstrated to cause peripheral and neuronal insulin resistance, and brain mitochondrial dysfunction in rats. Although the dipeptidyl peptidase-4 inhibitor, vildagliptin, is known to improve peripheral insulin sensitivity, its effects on neuronal insulin res...