Iron distribution and histopathological characterization of the liver and heart of β-thalassemic mice with parenteral iron overload: Effects of deferoxamine and deferiprone

• Main Authors: Yatmark P., Morales N.P., Chaisri U., Wichaiyo S., Hemstapat W., Srichairatanakool S., Svasti S., Fucharoen S.
• Format: Article
• Language: English
• Published: Urban und Fischer Verlag Jena 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84902819565&partnerID=40&md5=20636984207f34a1ae0e3f86d8b357bd; http://cmuir.cmu.ac.th/handle/6653943832/1727
• Institution: Chiang Mai University

The liver and heart are the major target organs for iron accumulation and iron toxicity in β-thalassemia. To mimic the phenomenon of heavy iron overload resulting from repeated blood transfusions, a total of 180mg of iron dextran was intraperitoneally injected into C57BL/6J mice (WT) and heterozygou...